High-Dose Intravenous Iron Replacement Therapy for Iron Deficiency Anemia Does Not Hinder Drug-Induced Amelioration of Disease Activity in IBD Patients

    February 2018 in “ The American Journal of Gastroenterology ”
    Stein Jìrgen, Stefan Vollmer, W Klemm, Nip Kerry, S Weber-Mangal, Dignass Axel
    TLDR High-dose iron therapy improves anemia without affecting IBD treatment.
    The study assessed the impact of high-dosed intravenous ferric carboxymaltose (FCM) on inflammatory activity in 224 IBD patients across 101 centers in Germany. Over approximately 12 weeks, patients received a mean total iron dose of 1,139mg. The study found that FCM therapy did not hinder the drug-induced reduction of inflammatory activity, as indicated by significant decreases in CRP levels and clinical disease activity indices (CDAI/CAI). Patients experienced improvements in hemoglobin, s-ferritin, and TSAT levels, along with reduced symptoms. The results suggested that high-dosed FCM is effective and does not interfere with the amelioration of disease activity in IBD patients.
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      in Treatment  7 upvotes 6 years ago
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      in Female  17 upvotes 1 year ago
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      in Is this regrowth? 3 months ago
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      in Chat  258 upvotes 11 months ago
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      in Research/Science  2 upvotes 2 months ago
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