Rare Skin Disorders in IBD Patients Treated with Anti-TNFs

February 2014 in “ Journal of Crohn's and colitis ”

Vanessa Prieto, Alexis Fernández, A. Velasco, Cecilia Pérez Piñero, Jazmina Umaña, Y. Jamanca, A Mora, Alvaro J. Ramos Rodriguez

alopecia universalis alopecia areata ustekinumab molluscum contagiosum podophyllin anti-TNFs Stelara

TLDR Some IBD patients on anti-TNFs developed severe skin issues, but ustekinumab helped.

In a study of 93 IBD patients treated with anti-TNFs, 6.45% developed severe psoriasiform reactions, necessitating the withdrawal of the treatment. Two patients (2.5%) developed alopecia universalis, with one having a history of alopecia areata, suggesting a potential risk factor. Ustekinumab was found to be an effective alternative for managing these adverse effects. Additionally, a case of molluscum contagiosum was resolved with podophyllin and cessation of immunosuppressive therapy.

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