research Next Generation Human Skin Constructs as Advanced Tools for Drug Development
Advanced human skin models improve drug development and could replace animal testing.
Search
for
Sort by
Research
510-540 / 1000+ results 
research Clinical Development of Topoisomerase-Interactive Drugs
New drugs targeting DNA enzymes show promise for cancer treatment but have side effects like immune system suppression and hair loss.
research A Potential Review of Its Traditional Uses, Phytochemistry, Pharmacology, and Toxicity of Plumbago Zeylanica
Plumbago zeylanica has valuable medicinal properties but needs sustainable cultivation methods.
research Chronic Toxicity Studies of the Potential Cancer Preventive 2-(Difluoromethyl)-DL-Ornithine
The study investigated the chronic toxicity of 2-(difluoromethyl)-dl-ornithine, a potential cancer preventive agent, in rats and dogs. In rats, high dosages (400, 800, and 1600 mg/kg) over 52 weeks caused weight loss, increased platelets, alopecia, skin issues, liver necrosis, and gastric inflammation, with 400 mg/kg being the no-effect dose. In dogs, dosages of 50, 100, and 200 mg/kg led to conjunctivitis, hyperkeratosis, alopecia, and cystic intestinal crypts, but a no-effect dose was not identified. Despite these toxicities, the study suggested that lower dosages might minimize adverse effects, supporting further clinical development of the compound.
research Baicalin Increases Hair Follicle Development by Enhancing Canonical Wnt/β-Catenin Signaling and Activating Dermal Papilla Cells in Mice
Baicalin helps hair growth by activating specific cell signals and pathways.
research Synthetic Studies Toward the Development of Novel Minoxidil Analogs and Conjugates with Polyamines
New minoxidil compounds with better water solubility were made, but their full effects and safety need more research.
research Chemistry, Pharmacology, and Therapeutic Potential of Decursin: A Promising Natural Lead for New Drug Discovery and Development
Decursin shows promise for treating cancer, neuroprotection, inflammation, and hair loss.
research Traditional Uses, Phytochemistry, Pharmacology, Toxicity and Clinical Application of Traditional Chinese Medicine Cynoglossum Amabile: A Review
Cynoglossum amabile has medicinal potential but poses safety concerns due to liver toxicity.
![Discovery of (2S)-N-(6-Cyano-5-(Trifluoromethyl)Pyridin-3-Yl)-3-(6-(4-Cyanophenyl)-3,6-Diazabicyclo[3.1.1]Heptan-3-Yl)-2-Hydroxy-2-Methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment](/images/research/693e7bf6-2325-4ddc-a20f-3470db9f4516/small/25627.jpg)
research Discovery of (2S)-N-(6-Cyano-5-(Trifluoromethyl)Pyridin-3-Yl)-3-(6-(4-Cyanophenyl)-3,6-Diazabicyclo[3.1.1]Heptan-3-Yl)-2-Hydroxy-2-Methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment
A new topical treatment for hair loss shows strong hair growth effects with low toxicity.
research Accelerated Wound Healing Using Nanoparticles
Nanoparticles can speed up wound healing and deliver drugs effectively but may have potential toxicity risks.
research Chapter 14: Principles of Drug Metabolism
Drug metabolism affects how long a drug works, its interactions, activation, and toxicity, and is influenced by genetics, diet, illness, and other drugs.
research The Human Gut Chemical Landscape Predicts Microbe-Mediated Biotransformation of Foods and Drugs
The study developed a tool to predict how gut microbes process foods and drugs, showing that similar compounds often share metabolic pathways and effects.
research Potential of Nano-Phytochemicals in Cervical Cancer Therapy
Nano-sized plant-based chemicals could improve cervical cancer treatment by being more effective and causing fewer side effects than current methods.
research Advances in Nucleoside Monophosphate Prodrugs as Anti-HCV Agents
New treatments for Hepatitis C show promise but need more research to confirm their safety and effectiveness for clinical use.
research Herbal Nano-Formulations for Topical Delivery
Herbal nano-formulations show potential for effective skin delivery but need more research.
research Glycol Ethers and Neurodevelopment: Investigating the Impact of Prenatal Exposures
Exposure to certain glycol ethers during pregnancy may be linked to lower verbal comprehension in children.
research Cutaneous Effects in Hormonal Contraception
Hormonal birth control can cause skin issues, but low-dose options and those with antiandrogens may reduce these effects.
research Safety, Tolerability, and Pharmacokinetics of Topical Calcitriol Formulation for Treatment of Chemotherapy-Induced Alopecia in Patients Receiving Taxane-Based Regimen: Final Results
Topical calcitriol was safe and well-tolerated for potential hair loss prevention in chemotherapy patients.
research Four Closure
Certain astrocytes can protect the brain and improve recovery after a stroke, and a hair loss drug might reduce cancer spread.
research Antiandrogen Therapy in Dermatology
Antiandrogens can help treat skin conditions like acne and excessive hair in women when used carefully.
research New Treatments for Rheumatoid Arthritis
New drugs for rheumatoid arthritis show improvement but have side effects and are not a cure.
research Human Regulatory T Cells: Role in Autoimmune Skin Diseases and Post-Transplant Nonmelanoma Skin Cancers
Understanding how Regulatory T Cells work could help create treatments for certain skin diseases and cancers.
research Integrative Medicine: Potential Applications in Dermatological and Endocrine Diseases - A Literature Review
Combining conventional and Chinese herbal medicine could help treat some skin and hormone-related diseases.
research Cinchona Pubescens (Cascarilla), Native Species From The Andes Mountains Of South America
Cinchona pubescens is a medicinal plant from the Andes with potential health benefits, but more research is needed to fully understand it.
research Skin Care Properties of Grape Seed Polyphenols, a By-Product of the Winery Industry
Grape seed extract is good for skin care, with antioxidant, anti-inflammatory, and anti-cancer effects.
research Triton Modified Polyethyleneimine Conjugates Assembled With Growth Arrest-Specific Protein 6 for Androgenetic Alopecia Transdermal Gene Therapy
The treatment effectively promotes hair regrowth in androgenetic alopecia without causing skin irritation.
research Transfollicular Enhancement of Gel Containing Cationic Niosomes Loaded with Unsaturated Fatty Acids in Rice Bran Semi-Purified Fraction
The gel with special fat-loaded particles from rice bran could be an effective skin treatment for hair loss.
research Light Emitting Diodes Technology-Based Photobiomodulation Therapy for Dermatology and Aesthetics: Recent Applications, Challenges, and Perspectives
LED light therapy is effective for skin and hair treatments but requires careful use to minimize risks.
research Costunolide: A Bioactive Sesquiterpene Lactone with Diverse Therapeutic Potential
Costunolide may have multiple health benefits, including promoting hair growth and protecting against cancer and diabetes, but more research is needed.
research Therapeutic Potential of Lawsonia Inermis Linn: A Comprehensive Overview
Henna has potential health benefits and can treat various conditions, but more research is needed to confirm safety and effectiveness.