Glycol Ethers and Neurodevelopment: Investigating the Impact of Prenatal Exposures

June 2017 in “ Environmental health perspectives ”

Nate Seltenrich

Studysummary Exposure to certain glycol ethers during pregnancy may be linked to lower verbal comprehension in children.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer ·

View this study on ehp.niehs.nih.gov →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community Propylene glycol vs ethyl alcohol(70% or 96%) for topical finasteride solution. Pros and cons?

4 upvotes 2 years ago

The conversation discusses the pros and cons of using propylene glycol versus ethyl alcohol in topical solutions for finasteride and minoxidil. It questions why propylene glycol is commonly used and whether ethyl alcohol might be a better option.

community The best Ethanol/Propylene Glycol ratio for home made topical finasteride?

4 upvotes 2 years ago

The conversation discusses the best ethanol and propylene glycol ratio for homemade topical finasteride, with a focus on absorption and drying issues. The user shares their experience using a 50% propylene glycol, 30% ethanol, and 20% water solution, and considers adjusting the ethanol content for better results.

community Finasteride - impact on Neurosteroids, which yes, \are important and not a garbage hormone

in Research/Science 163 upvotes 1 year ago

Finasteride may affect neurosteroids, impacting mood and sexual function, with varied user experiences. Some report side effects like depression and sexual dysfunction, while others find it effective for hair retention or prefer alternatives like Dutasteride or topical treatments.

community Are we underestimating systemic absorption with homemade/generic Topical Fin? (HPCH vs. PG/Ethanol formulations)

5 upvotes 7 months ago

Topical finasteride may have higher systemic absorption and lower efficacy when using a Propylene Glycol/Ethanol formulation compared to the hydroxypropyl chitosan (HPCH) formulation. The safety profile of topical finasteride relies heavily on the HPCH formulation, and using standard solutions might lead to different pharmacokinetics.

community Enlighten me about the role of ethanol and PG in topical solutions, where the ideal ratio of the two is, and why?

2 upvotes 10 months ago

The conversation discusses the use of ethanol and propylene glycol (PG) in topical solutions for hair loss treatments, specifically Minoxidil. The user dislikes the texture of PG and questions the ideal ratio and necessity of PG in these solutions.

community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

27 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

Similar Research

5 / 1000+ results

research Alterations in neonatal neurosteroids affect exploration during adolescence and prepulse inhibition in adulthood

35 citations , September 2009 in “Psychoneuroendocrinology”

Early-life neurosteroid changes affect adolescent exploration and adult behavior.

research Neuroactive Steroids and Ethanol Exposure: Relevance to Ethanol Sensitivity and Alcohol Use Disorders Risk

1 citations , January 2019 in “Elsevier eBooks”

This review suggests that GABAergic neuroactive steroids modulated by alcohol could play a role in vulnerability to alcohol use disorders, providing a rationale for further therapeutic exploration.

research Gene and tonic: Sonic hedgehog disruption and fetal alcohol syndrome

August 2011 in “Reproductive Toxicology”

research Relationship between neonatal allopregnanolone and neonatal stress: effects on adolescent and adult behaviour /

January 2017

This study found that neonatal administration of Allopregnanolone may mitigate some behavioral effects of early maternal separation in adolescence, but also lead to similar adverse effects as the separation in adulthood.

research Effects of neonatal and adolescent neuroactive steroid manipulation on locomotor activity induced by ethanol in male wistar rats

7 citations , May 2017 in “Behavioural brain research”

This study found that manipulating neuroactive steroids during early development stages in male rats influences alcohol-induced locomotor sensitivity, suggesting their role in addiction vulnerability.