Chronic Toxicity Studies of the Potential Cancer Preventive 2-(Difluoromethyl)-DL-Ornithine

January 1994 in “ Toxicological Sciences ”

James A. Crowell, Edwin I. Goldenthal, Gary J. Kelloff, WINFRED F. MALONE, CHARLES W. BOONE

2-(difluoromethyl)-dl-ornithine alopecia hyperkeratosis skin issues

TLDR Lower dosages of 2-(difluoromethyl)-dl-ornithine might reduce side effects, supporting further research.

The study investigated the chronic toxicity of 2-(difluoromethyl)-dl-ornithine, a potential cancer preventive agent, in rats and dogs. In rats, high dosages (400, 800, and 1600 mg/kg) over 52 weeks caused weight loss, increased platelets, alopecia, skin issues, liver necrosis, and gastric inflammation, with 400 mg/kg being the no-effect dose. In dogs, dosages of 50, 100, and 200 mg/kg led to conjunctivitis, hyperkeratosis, alopecia, and cystic intestinal crypts, but a no-effect dose was not identified. Despite these toxicities, the study suggested that lower dosages might minimize adverse effects, supporting further clinical development of the compound.

View this study on academic.oup.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community 2 year anniversary of Fin only - M48

in Is this regrowth? 212 upvotes 1 week ago

A 48-year-old man has been using finasteride at 1mg three times a week for two years, seeing some hair regrowth but noting lighting affects appearance. He is considering adding minoxidil but is concerned about shedding.

community 2 months into Minoxidil, poor sleep however, is it over for me?

in Minoxidil 47 upvotes 2 weeks ago

A 21-year-old university student started using Minoxidil and derma stamping for hair loss over two months ago. Despite poor sleep due to exams, the student is hopeful about improving their sleep schedule during the holidays and notes their hairline remains straight.

community 2 years of dut, great result i’ve seen, hairline is coming back

in Is this regrowth? 137 upvotes 3 weeks ago

The conversation is about a user sharing positive results from using dutasteride for hair regrowth over two years, with others discussing the effectiveness and experiences with hair loss treatments like finasteride and minoxidil. Some users request before-and-after photos to assess the effectiveness of the treatment.

community 2 Years on Fin + Min, No Improvement, Hair Worse Than Before

in General 92 upvotes 1 month ago

A user has been using Minoxidil and Finasteride for 2 years without improvement, experiencing worsening hair loss. They are considering other treatments like Dutasteride, PRP, and microneedling.

community 2 months since starting minoxidil 5% and alternating 1mg fin & 0.5mg dut 4/3, is this good progress given the timeframe?

in Journals / Progress Pictures 120 upvotes 1 month ago

The user started using minoxidil 5% and alternating 1mg finasteride with 0.5mg dutasteride, noticing some hair improvement after two months. They experienced side effects like watery semen and fluctuating libido, but also positive effects like reduced anxiety and clearer skin.

community 2.5 years Minoxidil and HRT, CPA->Lupron +Minox 5%

in Transgender 611 upvotes 1 month ago

The user experienced significant hair regrowth after 2.5 years of using Minoxidil 5% and hormone replacement therapy (HRT) with Lupron, despite initial scalp irritation. Finasteride was ineffective for them.

Similar Research

5 / 1000+ results

Polyamines and Hair: A Couple in Search of Perfection

research Enzymes

March 2008 in “British Journal of Pharmacology”

Enzymes play crucial roles in metabolism, health, and disease management.