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This letter highlights concerns about transient lymphadenopathy as a potential adverse effect of platelet-rich plasma combined with microneedling for alopecia, emphasizing the need to understand its underlying cause.

This review explores the development and cosmeceutical applications of microneedles for skin treatment, without reporting new clinical results, emphasizing safety and public perception as key factors for commercialization.

This review discusses advancements in the use of microneedle arrays and nanoparticles for transdermal delivery of therapeutics, noting challenges in overcoming the skin barrier and summarizing recent clinical trial achievements in areas like cancer therapy and gene therapy.

This article explains that skin microneedling promotes skin regeneration by creating microinjuries, which stimulate collagen and elastin production, making it effective for treating various skin issues with high effectiveness, limited side effects, and a short recovery time.

This review discusses various types of microneedles and their potential to expand the range of drugs delivered via the skin, but reports no new clinical results.

This review highlights the potential of microneedles as a low-cost, well-tolerated method for transdermal drug delivery in dermatology, though further research is needed to establish their clinical efficacy.

This source reviews advancements in microneedle-based cosmeceutical delivery, discussing new technologies and highlighting a burgeoning area of research involving microneedling combined with stem cell delivery for anti-aging, without finding measurable changes in skin barrier function or appearance during the study period.

In this study, AMP-303 injections demonstrated a trend toward increasing non-vellus hair count in men with mild to moderate androgenetic alopecia, notably showing a 14.5% peak increase at 60 days compared to saline, with effects lasting up to five months.

In this pilot study, the niostem device, a wearable device delivering low-level electrical stimulation, significantly increased hair density by 19.3% and thickness by 8.8% in male androgenetic alopecia patients over six months without reported adverse events.

This study developed a low-viscosity triamcinolone acetonide serum, used with a derma stamp microneedling device, to improve targeted treatment of alopecia areata, reporting favorable drug solubility, spreadability, and permeation to hair follicles, while maintaining skin safety.

AMP-303 injections can increase hair growth in androgenetic alopecia with minimal side effects.

In this study, combining stromal cells and PRP resulted in a significantly higher cell count and volume than using a saline group, suggesting increased potential efficiency; however, clinical outcomes need further evaluation.

Endré Mester is highly regarded as the 'Godfather' of phototherapy.

This study developed a new triamcinolone acetonide serum combined with a microneedling device, showing promise for treating alopecia areata by targeting hair follicles in a less invasive, patient-friendly way with confirmed drug solubility, compatibility, and safety.

This study found that polyamidoamine dendrimers can permeate skin's current conducting pores and alter the magnitude and direction of electroosmotic flow, affecting drug flux during iontophoresis.

This study found that a new autonomous, moisture-driven flexible electrogenerative dressing significantly accelerated chronic wound healing in a diabetic mouse model compared to the control group.

In a pilot study with 21 patients, the niostem device increased hair counts and density and enhanced testers’ self-perception of hair growth at 6 months without reported adverse effects, suggesting potential benefits for androgenetic alopecia.

In this study, a newly engineered scaffold, PADM-MX-Ag-Si@Dox, demonstrated potential as a multifunctional biomaterial for postoperative melanoma treatment by controlling drug release, enhancing wound healing, and enabling real-time tumor surveillance through temperature, pH, and electrical stimuli.

This study developed a spring-driven microneedle booster that improved early and cumulative delivery of minoxidil, accelerating hair regrowth compared to traditional roller methods in an androgenetic alopecia model.

This study found that the film-trigger applicator system enhanced drug delivery efficiency and skin penetration of dissolving microneedles compared to traditional patch systems in both lab and animal models.

The researchers developed semi-dissolving microneedle patches using TEMPO-oxidized bacterial cellulose nanofibers, which allow effective transdermal drug delivery by forming micro-channels for large drug quantities, overcoming traditional microneedles' low drug loading.

This study demonstrated that while the proposed placebo microneedle stamp design was partially successful in blinding participants with low skin sensitivity, further development of suitable placebo controls is needed.

In this study, researchers demonstrated that treating platelet rich plasma with microsecond pulsed electric fields effectively activates platelets and induces similar or higher growth factor release compared to traditional bovine thrombin, suggesting a potential clinical use that may be more cost-effective and practical.

This study found that combining electrical stimulation with minoxidil had a synergistic effect on the proliferation of cultured human dermal papilla cells, potentially through enhanced activation of the Wnt/β-catenin pathway.

In this study, researchers evaluated how subjects perceive the effectiveness of three FDA-cleared photobiomodulation devices for home use in treating androgenetic alopecia, though specific outcomes or comparative effectiveness are not reported in the abstract.

This study reports that a novel multimodal approach, combining tattoo machine–assisted drug delivery of hair loss treatments with oral and topical medications, may enhance hair density and thickness in androgenetic alopecia patients, though larger controlled studies are needed to confirm these early findings.

This study observed that DNA damage response (DDR) plays a key role in pressure overload-induced cardiomyocyte hypertrophy, with disruption of the ATM kinase pathway potentially modulating this hypertrophy in mice.

This study found that 308 nm excimer lamp therapy provides a good clinical response with fewer adverse effects for limited alopecia areata but is less effective for widespread hair loss like alopecia totalis.

Using Excimer light with topical steroids is the most effective treatment for alopecia areata.