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This study found that CD26+ fibroblasts are crucial for effective extracellular matrix production and achieving rapid epidermal and dermal homeostasis in human tissue-engineered skin substitutes transplanted onto rodents.

This study suggests that a novel micropatterned dermal–epidermal matrix (μDERM) enhances keratinocyte function and epidermal morphology, offering potential improvements in skin substitute design for wound healing applications.

This study found that composite skin constructs containing dermal papilla cells promoted better skin healing and hair regeneration in nude mice, highlighting their role in tissue-engineered skin for severe injuries.

This review evaluates the clinical use of composite dermal-epidermal skin substitutes, with a focus on advancements such as the "BioMask" for facial skin trauma, highlighting the potential of 3D bioprinting and bioengineered skin in improving wound treatment and reconstruction.

This review discusses current experimental approaches for regenerating human hair follicles using tissue engineering and isolated cells, but reports no successful strategies with adult cells yet found.

Tissue-engineered skin substitutes can model junctional epidermolysis bullosa and may help develop gene therapy.

In this study, epidermal stem cells were found to enhance blood vessel formation and support successful one-step transplantation of tissue-engineered skin in a rat model.

This study concluded that early-stage tissue-engineered skin substitutes, developed using skin progenitor cells, had a better graft efficiency and supported hair follicle formation, which may improve wound healing outcomes.

Early-stage skin substitutes improve wound healing and skin structure.

New skin substitutes for treating severe burns and chronic wounds are being developed, but a permanent solution for deep wounds is not yet available commercially.

This study observed that earlier-passage keratinocyte cultures led to superior hair follicle neogenesis in dermal-epidermal composites grafted onto immunodeficient mice, suggesting their potential utility in studying human hair follicle development.

This review highlights the global efforts and challenges in 3D bioprinting for developing skin substitutes, emphasizing the need for standardized protocols to enhance reproducibility and clinical applicability in wound healing and regeneration.

In this study, a bioengineered construct using a biodegradable polycaprolactone mat cocultured with human keratinocyte and rabbit dermal fibroblast cells demonstrated potential as a tissue-engineered skin substitute, showing good cell adhesion and growth.

This study found that the peptide TSN6 increased epidermal thickness and promoted hair follicle formation in dermal–epidermal composites grafted onto nude mice, with TSN6-treated composites showing more hair follicles and retained grafts compared to control groups.

This study found that microporous electrospun scaffolds with a 70:30 collagen I to poly(ɛ-caprolactone) ratio significantly accelerated wound closure and dermal regeneration in full-thickness critical-sized skin defects.

This study introduced a bioengineering platform that creates early-stage hair peg-like structures within tissue-engineered skin substitutes by integrating human keratinocytes and dermal papilla cells with laser-micropatterned collagen scaffolds, providing a foundation for future appendage-inclusive skin regeneration efforts.

This study demonstrates that trichogenic dermal papilla cells are crucial for hair regeneration in engineered skin substitutes, with adult murine cells showing higher activity than adult human cells.

This article discusses the factors contributing to acne and reports no new findings, focusing on the role of sebaceous lipids and associated processes.

This study demonstrated that cultured human dermal papilla cells can induce full hair follicle formation when combined with neonatal foreskin keratinocytes in a grafted dermal-epidermal construct on mice.

This study found that injecting a mixture of epidermal stem cells and dermal papilla cells can induce hair follicle regeneration and well-ordered epidermis formation in mice.

This study found that prevascularizing dermal matrices with adipose tissue-derived microvascular fragments improved vascularization and allowed earlier successful skin grafting in a bradythrophic wound model.

This study found that human dermal fibroblasts can promote the viability and proliferation of microvascular endothelial cells in vitro, revealing important interactions at play in hair growth.

In this study, researchers developed a new 3D skin equivalent assay using mouse epidermal and dermal cells that successfully regenerated organized hair follicles, outperforming a 2D model in hair follicle orientation and quantity, and enhanced hair growth when Wnt3a was added.

In this study, researchers observed that exposure to low-frequency electromagnetic fields enhanced hair follicle regeneration and formation of hair follicle-like structures in bioengineered skin in nude mice.

This study demonstrated in rodent models that artificial dermal template treatment can induce full-thickness skin regrowth including skin epidermis and adnexa without the need for autologous skin grafts.

This study found that overexpression of activin in transgenic mice led to enhanced granulation tissue formation after skin injury due to changes in keratinocyte proliferation and differentiation.

This study found that transplanted microencapsulated dermal papilla cells in rat footpads can regenerate hair follicles and sebaceous gland structures, suggesting a potential substitute for fresh dermal papillae cells.

This chapter discusses the composition, biocompatibility, and production methods of biomaterials like collagen, chitin, and silk for dermal substitutes, focusing on preclinical and clinical research, but reports no new clinical results.

In this mouse study, researchers found that dermal Wnt signaling/β-catenin activity is essential for fibroblast proliferation and initiating hair follicle formation by interacting with epidermal Wnt ligands.

This study found that epidermal stem cell-specific Jag1 expression levels are crucial for effective wound healing and scar reduction, and porcine acellular dermal matrix treatment enhances this process in mice by boosting Notch/Jagged1 signaling.