24 citations
,
March 2022 in “Stem Cell Research & Therapy” This study found that dendritic epidermal T cells and their exosomes enhance epidermal stem cell proliferation, accelerating wound re-epithelialization in the skin.
16 citations
,
February 2005 in “British journal of dermatology/British journal of dermatology, Supplement” This study found that VDR deficiency in mice leads to various skin pathologies but does not affect the phenotype or function of Langerhans cells.
7 citations
,
January 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that epithelial cells in the skin of live mice regulate the density and spatial organization of immune cells, which actively maintain their position despite constant cell turnover.
January 2026 in “British Journal of Dermatology” In this study, distinct immune and cellular profiles were observed in adults with atopic dermatitis associated with high levels of Staphylococcus aureus, including increased proinflammatory T cells and markers of skin barrier impairment, pointing to potential therapeutic targets for managing these interactions.
18 citations
,
May 2011 in “Journal of Investigative Dermatology” Wnt signaling affects the development and growth of Langerhans cells in mice.
1 citations
,
August 2013 in “The Journal of Cell Biology” This study found that Wnt secretion is important for skin homeostasis in mice, as Evi-deficient mice developed skin lesions resembling psoriasis and showed immune cell imbalance.
7 citations
,
September 1980 in “Zoological Journal of the Linnean Society” This study observed that dermal dendritic cells migrate to the epidermis in mouse tail and back skin, correlating with changes in epidermal physiology like ortho- and parakeratosis.
10 citations
,
January 2019 in “International Immunology” This review discusses the interactions between immune cells and the skin epithelium and their impact on maintaining barrier function, emphasizing the potential to enhance epithelial barrier function in inflammatory diseases.
9 citations
,
September 2009 in “PubMed” This case report presents the first evidence of significant antigen presenting cells around hair follicles in a patient with alopecia due to active systemic lupus erythematosus.
18 citations
,
September 1990 in “Veterinary Dermatology” This study in SPF lambs found that primary and secondary orf virus infections trigger similar skin responses, but the primary infection caused a more severe and prolonged reaction.
30 citations
,
January 2014 in “Journal of Controlled Release” This study concluded that combining cyanoacrylate skin surface stripping with particle-based antigen delivery effectively targets HIV-1 p24 protein to skin cells, supporting its potential for needle-free transcutaneous vaccination.
112 citations
,
January 2013 in “Experimental dermatology” This article offers a viewpoint on hidradenitis suppurativa pathogenesis, suggesting that impaired Notch signalling from γ-secretase mutations may drive inflammation and link the condition to other Th17-driven diseases.
2 citations
,
June 2013 in “In Vitro Cellular & Developmental Biology - Animal” This study successfully cultured human fetal hair follicle-derived melanocytes, which showed high proliferative capabilities and unique morphological characteristics compared to adult-derived cells, potentially advancing hair disease research.
57 citations
,
December 2012 in “Journal of Biomedical Optics” This review discusses the application of confocal laser scanning microscopy for studying nanoparticle interactions with skin and highlights its potential for broad applications, but reports no new experimental findings.
January 1994 in “Medical Entomology and Zoology” This article reviews various microscopy techniques and their applications in dermatology but reports no new experimental results.
51 citations
,
March 2022 in “Frontiers in Immunology” This review discusses the regulatory roles of type 2 alarmin cytokines in skin immunity, focusing on their implications in host defense, chronic inflammation, and cancer, but reports no new clinical results.
39 citations
,
January 2013 in “Journal of Investigative Dermatology” This review explains how recent understanding of Wnt signaling regulation in hair follicles could potentially be used to enhance hair growth, but it reports no new empirical results.
December 2012 in “Journal of dermatological science” This study reveals that hair follicles in mice and humans recruit epidermal Langerhans cells during skin inflammation via specific chemokine signaling pathways.
This study found that interleukin-1α and interleukin-7 secreted by keratinocytes enhance the proliferation of γδT-cells and epidermal stem cells, revealing mechanisms of stem cell activation during wound healing in mice.
This study found that IL-1α and IL-7 secreted from keratinocytes in a genetically engineered mouse model can stimulate the expansion of γδT-cells, aiding in the proliferation of epidermal stem cells for wound healing.
56 citations
,
November 1958 in “The Journal of Cell Biology” This study used electron microscopy to identify a distinct dendritic cell in the human epidermis, similar to the melanocyte, with unique structural features and variable melanin content.
69 citations
,
January 1995 in “PubMed” This study suggests that the structure and function of mouse melanocytes in the epidermis and hair bulb are influenced by genetic factors and local tissue environment, including hormones and growth factors.
January 2003 in “Linchuang pifuke zazhi” This study used atomic force microscopy to image surface structures of human epidermal melanocytes, hair follicle amelanotic melanocytes, and mouse melanoma cells, revealing differences in branch structure and granule distribution.
November 2025 in “Frontiers in Immunology” This review integrates studies on mouse models and human clinical observations to highlight the role of immune cells in skin development and how their dysregulation leads to skin disorders, suggesting potential therapeutic pathways for skin regeneration.
13 citations
,
June 2020 in “Scientific reports” In this study, melatonin administration enhanced various cellular and structural features of the scrotal skin in Soay rams, including increased thickness, cell count, and gland activity.
January 2019 in “Advances in stem cells and their niches” This review outlines the various fibroblast subsets in the skin dermis, their origins, and their influence on epidermal stem cell behavior, highlighting the role of the local dermal niche in stem cell plasticity.
1 citations
,
February 2025 in “Scientific Reports” In this study, researchers found that CD4 is expressed on murine K5+ keratinocytes, and its expression is crucial for maintaining epidermal stem cell balance and wound repair capacity, particularly during aging.
18 citations
,
November 2020 in “Frontiers in Cell and Developmental Biology” This review discusses how inflammation influences hair follicle stem cell activities like wound healing and follicle cycling and suggests a potential link between inflammation, stem cell activation, and programmed cell death.
January 2014 in “Durham e-Theses (Durham University)” In this study, the activation of Notch1 signaling in keratinocytes was found to play a key role in recruiting immune cells and facilitating skin repair after injury.
96 citations
,
July 2014 in “Cold Spring Harbor Perspectives in Medicine” This review discusses various stem cell compartments in adult murine and human epidermis, examining their expressed markers and characterization assays, and reports no new experimental results.