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Scientists have improved 3D models of human skin for research and medical uses, but still face challenges in perfectly replicating real skin.

The HoxC gene cluster and its enhancers are essential for developing hair and nails in mammals.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

The niche environment controls stem cell behavior and plasticity, which is important for tissue health and repair.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

β-Catenin signaling is involved in brain cell growth after injury and could be a therapy target.

Coffee silverskin may be a beneficial and safe ingredient for cosmetics, offering hydration, firmness, and potential hair growth benefits.

The conclusion suggests that PCOS may persist due to genetic traits that, while harmful for female fertility, could have provided survival and reproductive benefits to males.

New nano composite helps reduce scars and regrow hair during burn wound healing.

Syphilis is becoming more common and remains a major health problem due to challenges in prevention and treatment.

Activating TLR5 in the gut can extend lifespan and improve health in aged mice.

SOX2 is crucial for skin cell function and hair growth, and it plays a role in skin cancer and wound healing.

Steroid Sulfatase inhibitors show promise in treating hormone-dependent disorders like cancers, hair loss, and acne, with 667COUMATE being a potential candidate for breast cancer treatment trials.

New treatments and diagnostic methods for various animal skin conditions showed promising results.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

Astrotactin proteins are important for brain and skin development and are linked to several neurodevelopmental disorders.

A woman had an allergic skin reaction to a hair loss treatment containing canrenone.

The conclusion is that tissue structure is key for stem cell communication and maintaining healthy tissues.

ISCK03 stops melanin production in human melanoma cells and lightens skin color in mice and guinea pigs.

SOX9 helps determine stem cell roles by interacting with DNA and proteins that control gene activity.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

Hedgehog signaling helps keep hair follicle stem cells the same in both young and old human skin.

Gata6 is important for protecting hair growth cells from DNA damage and keeping normal hair growth.

Diabetex improves diabetic wound healing better than metformin.

Hormone imbalances from the pituitary, thyroid, and adrenal glands can cause infertility, but treating these disorders can improve fertility.

The document concludes that various hypersensitivity diseases in horses can be diagnosed and treated with methods like immunotherapy and medication, and early aggressive treatment is crucial for severe diseases like equine cutaneous pythiosis.

The circadian clock affects skin stem cell behavior, impacting aging and cancer risk.

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.

The document concludes that recognizing and properly diagnosing lipodystrophy syndromes is crucial for effective management and treatment.