Beta-Catenin Signaling Increases in Proliferating NG2+ Progenitors and Astrocytes During Post-Traumatic Gliogenesis in the Adult Brain

    December 2009 in “ Stem Cells ”
    Bryan D. White, Ryan J. Nathe, Don O. Maris, Nghi K. Nguyen, Jamie M. Goodson, Randall T. Moon, Philip J. Horner
    Image of study
    TLDR β-Catenin signaling is involved in brain cell growth after injury and could be a therapy target.
    The 2009 study explored the role of β-catenin signaling in the adult brain's response to traumatic brain injury (TBI), focusing on NG2+ progenitor cells and astrocytes. Using BATGAL reporter mice, the researchers found that β-catenin signaling increased in these cells, with a shift from NG2+ progenitors to GFAP+ astrocytes over time. The signaling was sustained in newly born cells and required cell division in the cortex. The study concluded that β-catenin signaling is involved in post-traumatic gliogenesis and could be a target for therapeutic intervention. The number of mice used in the TBI studies was 43, and for the spinal cord injury experiments, 9 mice were used, with statistical significance set at a p-value of 0.05.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 107 results

      community Anyone Try Microneedling with Exosomes/AAPE?

      in Microneedling  2 upvotes 3 years ago
      User asks where to purchase exosomes/AAPE for microneedling hair loss treatment. Links to research on hair regeneration therapy, stem cell therapy, exosome therapy, and dermal exosomes provided.

      community Does melatonin dissolve in isopropyl alcohol

      in Technology  7 upvotes 3 years ago
      The conversation discusses making a topical melatonin solution for hair loss treatment, questioning if isopropyl alcohol can dissolve melatonin. Melatonin is soluble in lipids and alcohol, but it's unstable and should be mixed fresh regularly; it may help hair growth by affecting certain cellular signaling pathways and has anti-androgenic effects.
      Improvements, features, announcements

      community Improvements, features, announcements

      by craggg in General  169 upvotes 1 year ago
      The conversation discusses improvements to a platform and mentions hair loss treatments including Minoxidil, finasteride, RU58841, and melatonin. It also highlights the addition of features like Google login, reply by email, keyword extraction, and a term glossary for better understanding of hair-related terminologies.

      community Opinions on Scalp fibrosis and DHT?

      in Research/Science  9 upvotes 3 years ago
      The conversation discusses the theory that scalp fibrosis contributes to male pattern baldness (MPB) by increasing DHT concentration, and mentions treatments like Minoxidil. The user seeks opinions on the theory and the effectiveness of scalp massages.

    Similar Research

    5 / 1000+ results