research Male Androgenetic Alopecia
Hair loss in men can be slowed or reversed with treatments like minoxidil and finasteride, but it resumes if treatment stops. It may also indicate early heart disease and obesity.
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450-480 / 1000+ results research Effects of 2-Ethylhexanoic Acid on Reproduction and Postnatal Development in Wistar Rats
The study investigated the reproductive toxicity of 2-ethylhexanoic acid (2-EHA) in Wistar rats, with 24 animals per sex per group receiving doses of 100, 300, or 600 mg/kg. Results showed a dose-dependent decrease in fertility, with increased time to mating and total infertility at higher doses. Male rats exhibited decreased sperm quality, with reduced motility and increased abnormal sperm at higher doses. The average litter size decreased by 16% at 600 mg/kg, and while birth weights were unaffected, body weight gain during lactation was slower. Pups showed delayed physical development and abnormal features at higher doses. A single 600 mg/kg dose given to pregnant females reduced implantations and caused resorptions. The study concluded that 2-EHA impaired fertility and delayed postnatal development, likely due to disturbed implantation and teratogenic effects.
research Nonscarring Hair Loss Disorders
Most types of hair loss can regrow naturally, but there are no effective cures for male pattern or age-related hair loss, and only limited options for females.
research Evaluation of Resistance Resources and Analysis of Resistance Mechanisms of Maize to Stalk Rot Caused by Fusarium Graminearum
Some maize lines resist stalk rot better due to specific genes and enzyme activities.
research Adverse Reactions to Biologic Medications Used in Allergy and Immunology Diseases
Biologic therapies can cause various adverse events, but allergy/immunology clinicians can manage them.
research Invasive Cutaneous Squamous Cell Carcinoma of Scalp: A Case Report
A man with a rare scalp cancer was successfully treated, highlighting the need for early management to prevent spread and complications.
research Dermal Hedgehog Signaling in Papillary Fibroblasts: An Emerging Key Player in Skin Regeneration
Hedgehog signaling in skin cells is crucial for hair growth and skin healing, but needs to be balanced to avoid harmful effects like scarring and cancer.
research Kartogenin Regulates Hair Growth and Hair Cycling Transition
Kartogenin may help treat hair loss by promoting hair growth and extending the hair growth phase.
research Retardation of Preputial Wound Healing in Rats with Hypospadias Induced by Flutamide
Flutamide-induced hypospadias in rats slows down early wound healing.
research Characterizing Hair Loss in the Elderly: An Observational Study of 163 Patients
Hair loss in elderly people is often due to health issues and needs better diagnosis and treatment.
research Practice and Educational Gaps in Dermatology
Dermatologists often neglect hair disorders due to complexity and lack of clear treatments, impacting patient care and highlighting the need for better education and interest in this area.
research Mechanism of Apoptotic Regulation of Follicular Regression
The document concludes that understanding how hair follicles naturally die and regenerate is important for insights into organ development and could impact health and disease treatment.
research Plasma β-Endorphin Concentrations During Natural and Artificially Induced Winter Hair Growth in Mink (Mustela Vison)
Melatonin and cortisol affect mink winter hair growth, but β-endorphin levels do not.
research The Hair Transplant Megasession Technique: A Review
Hair transplant megasessions are safe up to 1500 grafts but larger sessions have more risks and challenges.
research Mucosal TLR5 Activation Controls Healthspan and Longevity
Activating TLR5 in the gut can extend lifespan and improve health in aged mice.
research Vitamin D Receptor Cross-Talk With P63 Signaling Promotes Epidermal Cell Fate
Vitamin D helps skin stem cells heal wounds by working with a key skin protein.
research Melatonin Promotes the Development of Secondary Hair Follicles in Adult Cashmere Goats by Activating the Keap1-Nrf2 Signaling Pathway and Inhibiting the Inflammatory Transcription Factors NFkB and AP-1
Melatonin improves cashmere goat hair quality by increasing follicles and reducing skin aging.
research Viruses, Variants, and Vaccines: How COVID-19 Has Changed the Way We Look at Skin
COVID-19 and vaccines cause various skin reactions and highlight the need for dermatologists in managing these issues and addressing vaccine distribution disparities.
research Hair Growth Regulation by Fibroblast Growth Factor 12 (FGF12)
FGF12 is important for hair growth and could be targeted for hair loss treatment.
research Cyclin-Dependent Kinase 4 Expression Alters the Number of Keratinocyte Stem Cells in the Mouse Hair Follicle
Changing CDK4 levels affects the number of stem cells in mouse hair follicles.
research Maculopapular Rash Upon Antibiotic Therapy in a Patient with Rheumatoid Arthritis
Methotrexate caused a rare skin rash in a rheumatoid arthritis patient, which resolved after stopping the drug.
research A Novel Effect of Acyclovir on Hair Growth in BALB/c Mice: A Promising Future for Finding a New Topical Drug for the Treatment of Hirsutism
Acyclovir cream may slow down hair growth, suggesting it could be a new treatment for excessive hairiness.
research DNA Methylation as an Epigenetic Memory Keeper During Skin Development and Regeneration
DNA methylation is essential for skin and hair follicle development, and could be a target for treating skin diseases.
research Scaffold-Assisted Artificial Hair Implantation in a Rat Model
Artificial hair implantation using scaffolds is possible and PHDPE is more biocompatible than ePTFE.
research Inherited Hair Disorders
Genetic hair disorders can indicate other hidden health problems.
research FGF Signaling for Hair Cycle Resting Phase Alleviates Radiation Alopecia
FGF18 treatment during hair's resting phase can protect against hair loss from radiation.
research The Role of Glucosylceramides in Keratinocyte Differentiation and Epidermal Barrier Function
Glucosylceramides are essential for healthy skin and proper wound healing.
research Topically Applied Minoxidil in Baldness
Minoxidil, when applied to the scalp, can stimulate hair growth but effects vary, stop if treatment ends, and it may cause side effects like fluid retention.
research Epidermal cell proliferation and modulation of the protective potency of dexamethasone against phorbol ester-induced ornithine decarboxylase activity
The study investigated the effects of dexamethasone (DXME) on mouse skin treated with 12-O-tetradecanoyl-phorbol-13-acetate (TPA). DXME, when applied after TPA, inhibited both the dermal inflammatory reaction and the induction of epidermal ornithine decarboxylase (ODC) activity. During the hyperplastic stage, DXME continued to counteract inflammation but only weakly inhibited ODC induction. Interestingly, in DXME-protected skin, the hyperplastic stage was delayed, and TPA strongly induced ODC activity in the epidermal cell layer before this stage. The study suggested that as the proliferation process was induced, epidermal cells became more sensitive to TPA, potentially becoming less reliant on inflammatory factors for ODC induction.
research Reconstruction of a Sideburn by a Rotated Flap
Doctors successfully rebuilt a sideburn using skin and hair from near the ear in one surgery.