Vitamin D Receptor Cross-Talk With P63 Signaling Promotes Epidermal Cell Fate
September 2023
in “
Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology
”
Vitamin D receptor VDR p63 signaling epidermal cell fate stem cell activation skin wounding hair follicles stem cell loss cell differentiation cell migration interfollicular epidermis super-enhancer epidermal master regulator p63 skin cells stem cells skin injury hair roots cell loss cell growth cell movement skin surface enhancer skin regulator
TLDR Vitamin D helps skin stem cells heal wounds by working with a key skin protein.
The study "Vitamin D receptor cross-talk with p63 signaling promotes epidermal cell fate" investigates the role of Vitamin D and calcium signaling in the control of stem cell activation and function during the initial response to skin wounding. The researchers found that stem cells in the skin and hair follicles express high levels of Vitamin D Receptor (VDR), and that the removal of VDR leads to stem cell loss, decreased activation, and delayed differentiation and migration of progeny after wounding. The study also found that VDR is required for injury-induced cell fate conversion towards interfollicular epidermis. Furthermore, the study explored the molecular foundations for VDR to drive epidermal fate through super-enhancer associated cross-talk with the epidermal master regulator p63. The study used mice as subjects, but the exact number of mice used was not specified in the document.
