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research Vitamin D receptor cross-talk with p63 signaling promotes epidermal cell fate

1 citations , June 2023 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

This study found that deleting the vitamin D receptor from specific stem cells in mouse hair follicles disrupts their ability to regenerate the epidermis after injury, suggesting an essential interaction with the transcription factor p63.

research Epidermal stem cell fate: what can we learn from embryonic stem cells?

15 citations , September 2007 in “Cell & tissue research/Cell and tissue research”

This study suggests that human embryonic stem cells may improve skin graft quality and functionality by enabling the identification and amplification of early ectodermal progenitors, pending confirmation from preclinical studies.

research Neuregulin3 alters cell fate in the epidermis and mammary gland

39 citations , September 2007 in “BMC developmental biology”

This study found that Neuregulin3 can influence the development and differentiation of mammary glands and epidermal features in mice, potentially by inducing c-Myc and altering cell proliferation and adhesion.

research Extracellular Matrix as a Regulator of Epidermal Stem Cell Fate

57 citations , March 2018 in “International Journal of Molecular Sciences”

This review highlights recent advances in understanding how the extracellular matrix regulates epidermal stem cell fate, emphasizing the importance of the hair follicle stem cell niche, but reports no new empirical findings.

research Pgc-1α controls epidermal stem cell fate and skin repair by sustaining NAD+ homeostasis during aging

22 citations , August 2022 in “Molecular Metabolism”

This study identified a crucial role for epidermal Pgc-1α in regulating NAD+ signaling and influencing skin repair, with its dysfunction contributing to age-related wound healing defects.

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community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 3 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community Summary of Procapil video by Haircafe

2 upvotes 1 year ago

Procapil is marketed as a natural hair loss treatment but lacks strong evidence and is industry-biased. Minoxidil and Finasteride are the only FDA-approved treatments for androgenetic alopecia.

community Story time! The Great Unbalding (PP405)

230 upvotes 11 months ago

PP405 is a promising new hair loss treatment that may reactivate dormant hair follicles without side effects. It could surpass traditional treatments like minoxidil and finasteride if successful in further trials.

community The end of balding: We may have just found the secret to hair regrowth

in Technology 680 upvotes 1 year ago

MCL-1 is important for hair follicle stem cell survival, but its impact on human hair regrowth is unclear. Minoxidil and finasteride are the main treatments, with doubts about new discoveries leading to effective human solutions soon.

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