Role of β-catenin signalling in adult epidermal cell fate specification
January 2005
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Doctoral thesis, University of London.
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research Platelet-Derived Growth Factor Signaling Modulates Adult Hair Follicle Dermal Stem Cell Maintenance and Self-Renewal
PDGF signaling is crucial for maintaining and renewing hair follicle stem cells, which could help treat hair loss.
research Activation of Beta-Catenin Signaling in CD133-Positive Dermal Papilla Cells Drives Postnatal Hair Growth
Activating β-catenin in certain skin cells speeds up hair growth in mice.
research Dermal Sheath Cells Contribute to Postnatal Hair Follicle Growth and Cycling
Skin sheath cells help in hair growth and renewal after birth.
research Polyclonal Origin and Hair Induction Ability of Dermal Papillae in Neonatal and Adult Mouse Back Skin
Dermal papillae cells, important for hair growth, come from multiple cell lines and can be formed by skin cells, regardless of their origin or hair cycle phase. These cells rarely divide, but their ability to shape tissue may contribute to their efficiency in inducing hair growth.
research Differential sensitivity of epidermal cell subpopulations to β-catenin-induced ectopic hair follicle formation
research Progress on hair follicle stem cells
The document discussed the role of hair follicle stem cells in hair follicle morphogenesis and cycling, highlighting their location in the bulge area of the outer root sheath. These stem cells were characterized by slow cycling, multipotential differentiation, and self-renewal abilities. The surrounding microenvironment, particularly dermal papilla cells, played a crucial role in their proliferation and differentiation. Two main hypotheses, the bulge activation hypothesis and the stem cell migration hypothesis, were proposed to explain stem cell involvement in hair follicle morphogenesis and cycling. Key signaling pathways, including Wnt, BMP, and Shh, were identified as critical in these processes, with β catenin and LEF1/TCF being essential for converting stem cells to matrix cells and initiating hair follicle keratin gene expression.
research Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle
research Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis
Hair follicle stem cells can form both hair follicles and skin.