Plasma β-Endorphin Concentrations During Natural and Artificially Induced Winter Hair Growth in Mink (Mustela Vison)

    October 1999 in “ Annals of the New York Academy of Sciences ”
    Jack Rose, Kevin Wood, James T Billingsley, Joy Olbertz, Andrew T. Lovering, James A. Carr
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    TLDR Melatonin and cortisol affect mink winter hair growth, but β-endorphin levels do not.
    The study investigated the role of plasma β-endorphin and ACTH in the initiation of winter hair growth (anagen) in mink. Treatments with melatonin (MEL) or bilateral adrenalectomy (ADX) induced early anagen, but plasma β-endorphin levels did not change during natural anagen onset. ADX increased β-endorphin levels, but supplementation with cortisol (CORT) delayed anagen. MEL-induced anagen was not mediated by β-endorphin/ACTH, and CORT inhibited anagen through direct skin effects. The study suggested that local production of ACTH and β-endorphin in the skin might be necessary for anagen induction. Further research was planned to explore MEL binding sites and POMC expression in mink skin.
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