November 2019 in “Synapse” Brain-made chemicals can control nerve cell function differently in various parts of a mouse's brain, which may help us understand neurological conditions.
November 2012 in “Endocrine Practice” Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.
50 citations,
February 2013 in “Annals of Clinical Biochemistry” Understanding how DHT works is important for diagnosing and treating hormone-related disorders.
44 citations,
July 2012 in “Endocrine Practice” We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.
24 citations,
April 2008 in “Fertility and sterility” Pioglitazone improved insulin sensitivity and altered cortisol metabolism in PCOS patients.
December 2023 in “International journal of molecular sciences” Chromosomal differences affect how muscle cells respond to testosterone.
Androgenetic alopecia, or hair loss, is caused by a mix of genetics, hormones, and environment, where testosterone affects hair growth and causes hair to become smaller and grow for a shorter time.
21 citations,
May 2018 in “Journal of Cosmetic Dermatology” Costunolide helps human hair cells grow and can stimulate hair growth in mice.
5 citations,
November 2003 in “Biomedical Papers of the Faculty of Medicine of Palacký University, Olomouc Czech Republic” The exact causes of baldness are not fully understood, limiting treatment options.
4 citations,
August 2021 in “Annals of Translational Medicine” Dihydroartemisinin helps reduce prostate enlargement in rats by stopping the growth of prostate cells.
2 citations,
January 2023 in “Pharmaceuticals” Natural products and phytochemicals may help with hair regrowth, but more research is needed.
2 citations,
February 2019 in “JOJ dermatology & cosmetics” Anagen grow, a herbal hair serum, effectively promotes hair growth and could be an alternative to finasteride and beneficial for Minoxidil users.
1 citations,
December 2021 in “Androgens” Testosterone and its metabolites affect brain functions and could help treat neurological disorders.
Hair RiseTM microemulsion effectively promotes hair growth and treats hair loss better than standard treatments.
September 2024 in “International Journal of Molecular Sciences” Hydrangea serrata extract may promote hair growth and improve hair health.
February 2024 in “International Journal of Molecular Sciences” Hair loss in Androgenetic Alopecia is caused by genetics, aging, and lifestyle, leading to hair follicle shrinkage and related health risks.
January 2024 in “Journal of Biosciences and Medicines” Future treatments for androgenic alopecia may focus on reactivating hair follicle stem cells and improving drug delivery.
Minoxidil and finasteride are the only FDA-approved treatments for hair loss caused by genetic and hormonal factors, but their effectiveness is often doubted, indicating a need for new treatments.
January 2022 in “Current Enzyme Inhibition” New nonsteroidal molecules can potentially increase dihydrotestosterone in neurons by blocking certain enzymes, without affecting prostate and seminal vesicle weight.
8 citations,
February 2022 in “Molecules” Asparagus racemosus root extract reduced sebum and pore size in men but not in women.
6 citations,
October 2014 in “Experimental Dermatology” Prostaglandins and the enzyme AKR1C3 could play a role in skin cancer and hair loss, and further research is needed to understand these mechanisms.
December 2023 in “Revista Urología Colombiana / Colombian Urology Journal” More research is needed to find effective treatments for sickle cell disease-related priapism.
April 2023 in “Dermatologica Sinica” Sex hormones affect hair growth and loss, and treatments for related hair diseases include various medications, hair transplantation, and light therapy.
149 citations,
January 2011 in “Nature reviews. Urology” Hormonal interactions, especially involving DHT and estrogen, play a key role in BPH development and treatment.
16 citations,
April 2017 in “Journal of Cosmetic Dermatology” Ficus carica leaf extract may help treat skin disorders by reducing inflammation and androgen effects in skin cells.
12 citations,
January 2019 in “Journal of Endocrinology” Baicalin may help reduce excessive male hormone levels in PCOS.
1 citations,
February 2017 in “Journal of gynecology and womens health” The document concluded that more research is needed to understand how estrogen affects the enzyme involved in hirsutism development.
May 2004 in “Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease” Vitamin E affects liver metabolism, enhancing stress resistance, reducing blood clotting, and altering hormone processing.
March 2023 in “Journal of Drugs in Dermatology” Hormonal therapies, especially antiandrogens, can help manage Hidradenitis Suppurativa.
3 citations,
October 2022 in “Frontiers in Surgery” Proteomics combined with other technologies can lead to a better understanding of skin diseases.