This study found that activation of delta-opioid receptors in keratinocytes may delay the expression of the PER2 gene, suggesting a possible link to cancer development through circadian rhythm disruption.
4 citations
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June 2023 in “Journal of developmental biology” In this study, researchers propose that different vertebrate skin appendages, such as hair, feathers, and scales, evolved in parallel from a shared ancestral cell structure associated with teeth, dating back approximately 420 million years ago.
This review outlines the applications of intralesional steroid therapy, particularly triamcinolone acetonide, in several dermatological conditions and suggests further trials for certain uses but reports no new clinical findings.
6 citations
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January 2018 in “Dermato-endocrinology” This study found that acanthosis nigricans in the knuckles correlates with higher insulin and HOMA-IR values, potentially serving as an early, accessible marker for insulin resistance even without excess weight.
10 citations
,
June 2011 in “Movement Disorders” THAP1 gene changes do not affect DYT1 dystonia; finasteride may help reduce tics and OCD in Tourette syndrome.
161 citations
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June 1993 in “Journal of Biological Chemistry” This study suggests that human trichohyalin may function as a flexible rod linking keratin intermediate filaments and as a scaffold protein in hair follicle and epidermis cell envelopes.
62 citations
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January 2009 in “Biochemistry” This study found that both the natural ligand 1alpha,25(OH)(2)D(3) and the synthetic agonist LG190178 bind similarly to the vitamin D receptor's coregulator motifs, suggesting similar biological functions.
9 citations
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March 2009 in “The journal of investigative dermatology/Journal of investigative dermatology” This study reports that the maintenance and morphogenesis of skin appendages rely on both the dose and duration of ectodysplasin signaling.
50 citations
,
January 1986
September 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that zebrafish and stickleback fish use similar genetic programs for tooth regeneration, despite differences in their dental structures.
19 citations
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February 2013 in “Journal of Investigative Dermatology” Touch domes in human skin are complex sensory structures not directly linked to hair.
March 2026 in “Calcified Tissue International” This review discusses the complex role of the EDA pathway in vertebrate skeletal development, emphasizing its interaction with other morphogenic pathways to influence skeletal diversity, but reports no new experimental results.
February 2026 in “Journal of Cutaneous and Aesthetic Surgery” In this study, a case of a 20-year-old woman revealed ectopic acanthosis nigricans at a post-syndactyly-release surgical site, suggesting this rare condition could result from epidermal–dermal mismatch and altered growth factor signaling in grafted skin, without indicating any metabolic or malignancy concerns.
68 citations
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April 2014 in “Journal of Investigative Dermatology” This study identified a new S100 fused-type protein, scaffoldin, in reptiles and birds and suggests that SFTP-positive epithelia serve as scaffolds for the growth of various skin appendages, indicating a common evolutionary origin.
December 2025 in “Clinical Case Reports” In this study, researchers reported that dermoscopic examination of eyebrow hairs can help in the early diagnosis of Netherton syndrome in children by detecting trichorrhexis invaginata, facilitating prompt counseling and care while awaiting genetic test results.
5 citations
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January 2005 in “Journal of Enzyme Inhibition and Medicinal Chemistry” This study found that certain steroidal compounds, especially 10a–10c, demonstrated strong antiandrogenic activity by binding to the androgen receptor and reducing prostate weight in a hamster model.
25 citations
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January 2011 in “Pharmacognosy magazine” This study found that Nardostachys jatamansi DC rhizome extracts and specific isolated terpenoids promoted hair growth.
July 1976 in “Archives of Dermatology” This correspondence reports that using cantharidin on warts can result in lymphangitis, and dermatologists should consider all potential complications of treatments.
June 2025 in “Journal of Drug Delivery Science and Technology” A dissolving microneedle patch with dutasteride offers effective, long-lasting hair loss treatment with fewer side effects.
June 2020 in “Zenodo (CERN European Organization for Nuclear Research)” This study found that all five toxic microelements analyzed were most prevalent in the Caspian thin-fingered gecko's bone and muscle tissues, suggesting their tolerance to these elements in polluted areas.
January 2011 in “Journal of the American Academy of Dermatology” This book critiques Dr. Conroy's theory on Morgellon's disease, highlighting a lack of scientific evidence and detailing his unverified claims about fungal organisms attracted to cocaine.
July 2019 in “Indian dermatology online journal” This case report highlights an unusual trichoscopic appearance in alopecia areata due to dithranol staining, which may obscure typical patterns and reveal atypical vascular features in the interfollicular spaces.
December 2025 in “Pomeranian Journal of Life Sciences” This case report describes a man who developed localized acquired hypertrichosis due to inflammation and local pressure from over 20 years of working in mining, finding no statistical difference in hair thickness between his shoulders.
1 citations
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October 2019 in “International journal of contemporary pediatrics” This case report highlights a 12-year-old boy with twenty nail dystrophy in isolation, emphasizing the need for thorough physical exams to distinguish nail disorders and provide appropriate management and counseling on the condition's benign nature and good prognosis.
17 citations
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February 2022 in “Microscopy Research and Technique” This study reports that different animal species exhibit distinct hair scale patterns and elemental compositions, which can aid forensic investigations in identifying animal hair.
3 citations
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February 2019 in “Disease Markers” This study reports that a lower 2D:4D finger length ratio is significantly associated with higher disease activity and reduced spinal mobility in females with ankylosing spondylitis, but not in males.
7 citations
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April 1996 in “Archives of dermatological research” This study found that after topical application in rats, 1,24-dihydroxyvitamin D3 absorbed through both the stratum corneum and hair follicles, with about 30% excreted via the faeces.
60 citations
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August 1969 in “British Journal of Dermatology” This study used an autoradiographic technique to observe that germicides in surfactants are primarily deposited on the stratum corneum of guinea-pig and human skin.
August 2002 in “Analytical Sciences” The document concludes that a compound with potential for treating prostate cancer and hair loss was successfully made and its detailed structure was confirmed.
January 2024 in “Skin Appendage Disorders”