Crystal Structure and Synthesis of 17α-Acetoxy-4-Bromopregn-4-Ene-3,20-Dione
August 2002
in “
Analytical Sciences
”
TLDR The document concludes that a compound with potential for treating prostate cancer and hair loss was successfully made and its detailed structure was confirmed.
The document from 2002 detailed the synthesis of 17α-acetoxy-4-bromopregn-4-ene-3,20-dione, a potential antiandrogen useful for treating diseases like prostate cancer and androgenic alopecia. The compound was created from 17α-acetoxyprogesterone and its structure was confirmed through X-ray crystallography, revealing an orthorhombic crystal system with a formula weight of 451.40. The molecular structure included three six-membered rings and one five-membered ring with normal bond lengths and angles, and specific trans stereochemistry. Additionally, intermolecular C-H...O interactions were noted in the crystal structure. The research was financially supported by DGAPA, UNAM.
