January 2002 in “Europe PMC (PubMed Central)” This study presents a follicular automaton model that simulates human hair cycle dynamics and can reproduce hair patterns similar to diffuse or androgenetic alopecia by incorporating spatially heterogeneous parameters and follicle miniaturization.
July 2023 in “Nature Reviews Chemistry” A new method strengthens hair without using harmful chemicals.
3 citations
,
June 2025 in “Drug Design Development and Therapy” This review highlights the role of disrupted glycolysis in exacerbating reproductive and metabolic abnormalities in PCOS and suggests that agents like metformin and resveratrol may help restore glycolytic balance and improve ovarian function.
41 citations
,
September 2003 in “Journal of Investigative Dermatology” This study suggests that the COX-2 enzyme plays a role in hair follicle biology, as transgenic overexpression in mice induced hair follicle cycling disturbances and alopecia, which was mitigated by COX-2 inhibition.
29 citations
,
April 2020 in “Biomolecules” This review discusses the potential biomedical and clinical applications of brassinosteroids, highlighting their observed antiviral, anticancerous, and other bioactivities in animal test systems, but reports no new findings.
8 citations
,
January 2016 in “Journal of Investigative Dermatology” This review discusses the use of the human-on-mouse xenograft model for studying the human hair follicle cycle and emphasizes its utility for pharmacological testing, without reporting new clinical results.
18 citations
,
February 2015 in “Acta Crystallographica Section D: Structural Biology” This study reports that Ca 2+ binding alters the dynamics and surface properties of PKD-like domains in Clostridium histolyticum collagenases, enhancing their stability and potentially aiding in collagen-targeting vehicle development.
January 2019 in “Open Access Journal of Nursing” This study found that the self-care management process for Thai women with PCOS was centered around managing fertility, leading to lifestyle modifications to address amenorrhea and associated symptoms.
53 citations
,
July 1981 in “Journal of Endocrinology” In this study, α-MSH and cyclic AMP were found to stimulate melanogenesis in hair follicle cultures, while cyclic GMP and melatonin inhibited melanin production but not tyrosinase activity.
72 citations
,
February 2011 in “American Journal of Biological Anthropology” This study observed that eliminating positional error in hair segment analysis can improve understanding of changes in isotopic composition, aiding the identification of pathological conditions and dietary patterns.
25 citations
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May 2016 in “Molecular biology of the cell” This study found that the AtSfh1 protein in Arabidopsis is essential for phosphatidylinositol-4,5-bisphosphate signaling crucial to polarized root hair growth, utilizing both phosphatidylinositol and phosphatidylcholine-binding activities.
November 2012 in “Journal of Clinical Pathology”
21 citations
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October 2013 in “Molecular Biology of the Cell” This study found that the protein CCN2 in dermal papilla cells is a physiologically relevant suppressor of hair follicle formation by destabilizing β-catenin, which may help maintain stem cell quiescence.
75 citations
,
September 2015 in “Acta biomaterialia” This study found that alkylation of kerateine cysteine residues created a cell-compatible method for controlling hydrogel erosion rates and therapeutic agent release in keratin-based systems.
179 citations
,
July 2005 in “Human Reproduction Update” This review discusses the genetic basis and familial patterns of polycystic ovary syndrome, noting a strong familial component but inconclusive genetic patterns; it reports no new empirical findings.
161 citations
,
June 1994 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that the switch-off of melanogenesis during the hair cycle in C57 BL-6 mice is a gradual and stochastic process starting in mid anagen VI, with specific biochemical markers indicating the transition to catagen.
8 citations
,
January 2018 in “Journal of the American Academy of Dermatology” This study found that maintenance treatment with diphenylcyclopropenone was associated with a lower relapse rate in alopecia areata patients, highlighting the importance of adjusting treatment intervals post-improvement.
1 citations
,
September 2025 in “PLoS ONE” This study found that disrupted cholesterol homeostasis in scalp samples from cicatricial alopecia patients hinders hair regrowth by affecting hair follicle stem cell markers, with resulting effects confirmed in vitro and in animal models.
155 citations
,
August 2003 in “Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution” This review discusses the conserved molecular mechanisms controlling hair follicle development and cycling and suggests they may also apply to other ectodermal derivatives, like teeth and feathers, but it reports no new results.
6 citations
,
January 2020
November 2025 in “Fertility Gynecology and Andrology” This study highlights that polycystic ovary syndrome develops through genetic and environmental factors, with insulin resistance as a key mechanism, impacting the risk of metabolic and cardiovascular conditions.
3 citations
,
April 2018 in “Journal of Investigative Dermatology” CCCA may be a fibroproliferative disorder, and anti-fibrotic therapies could help.
June 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” This study found that a synthetic polyphenol, dimeric 1,2,4-benzenetriol (diBTO), can coat gray hair and gradually oxidize, creating a resistant brown layer similar to apple browning, which offers a practical hair dyeing solution that withstands washing and reduces the need for long dyeing sessions.
149 citations
,
July 2017 in “PLoS Biology” This study found that hair follicle patterning in development may arise from a combination of epidermal prepattern signals and mesenchymal self-organisation, with fibroblast growth factor and bone morphogenetic protein activities playing key roles.
124 citations
,
August 1994 in “Journal of Investigative Dermatology” This study found that applying dexamethasone to mice induced catagen-like follicle changes significantly earlier and more consistently than a vehicle, such changes being useful for studying hair follicle regression.
1 citations
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August 2016 in “Dermatology - Open Journal” In this study, the researchers found that optic atrophy 1 (OPA1) is involved in the transition between filamentous and rounded mitochondria in hair follicle dermal papilla cells, potentially influencing cellular energy dynamics.
521 citations
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January 1954 in “Physiological Reviews” Hair growth is cyclic and influenced mainly by local factors.
14 citations
,
September 1983 in “Acta Dermato Venereologica” This study found that daily topical application of citral increased sebaceous gland lobules and cell hyperplasia in male rats after three months.
This source discusses the growing trend of drug repurposing, a strategy that seeks new uses for existing drugs to overcome challenges like lengthy timelines and high costs in the traditional drug development process.
November 2018 in “International Journal of Current Pharmaceutical Research” This review discusses the causes, underlying mechanisms, diagnosis, and treatment strategies for polycystic ovary syndrome but reports no new clinical findings.