Shaping Up Mitochondrion in Motion

    August 2016 in “ Dermatology - Open Journal ”
    Chie Mifude, Kuniyoshi Kaseda
    TLDR Mitochondria change shape to meet energy needs during cell movement.
    The study reported that hair follicle dermal papilla cells (HFDPCs) contained two types of mitochondria: filamentous and rounded. Platelet-derived growth factor-AA (PDGF-AA) shifted the balance towards filamentous mitochondria, which produced more ATP and were present during cellular migration. The inner membrane protein optic atrophy 1 (OPA1) was involved in the transition between filamentous and rounded mitochondria, suggesting it provided rigidity to filamentous mitochondria. In contrast, other cells like breast cancer cells used small fragmented mitochondria during migration. The study discussed the regulation of mitochondrial morphology across different cellular systems, noting that mitochondria generally became slender or smaller during energy-demanding activities.
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