July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that locally administering thymic stromal lymphopoietin (TSLP) promotes hair growth by stimulating hair follicle cell proliferation during both normal conditions and after skin injury in mice.
This review discusses the potential role of extracellular vesicles in hair follicle cycling and future alopecia treatments but provides no clinical results.
June 2020 in “Nihon Ika Daigaku Igakkai Zasshi” This study found that aPKCλ, but not aPKCζ, plays a critical role in maintaining hair follicle stem cell populations and promoting wound healing in the epidermis.
March 2020 in “Research Square (Research Square)” This study identified 2884 long non-coding RNAs (lncRNAs) associated with hair follicle cycling in yaks and highlighted sequence conservation with cashmere goats, suggesting potential pathways for hair growth regulation.
December 2017 in “British Journal of Dermatology” Targeted therapy for skin cancer is complex due to the role of the hedgehog pathway in both cancer and hair growth.
September 2016 in “Journal of Dermatological Science” This study investigated the effects of Wnt-3a, Wnt-5a, Wnt11, and Wnt-10b on the hair induction-ability of cultured dermal papilla cells.
April 2016 in “Journal of Investigative Dermatology” Iron deficiency causes hair loss by affecting hair differentiation and cycling.
This study found that miR-22 regulates hair loss in mice by causing premature regression of hair follicles and suggests the importance of the microRNA regulatory network in understanding hair cycling and loss.
Recent discoveries have improved our understanding of hair loss, but challenges in treatment and knowledge among specialists still exist.
This study found that human growth hormone encapsulated in nano-liposome increased the number of hairs and stimulated hair cycling in mice, suggesting potential benefits for addressing hair loss.
April 2010 in “Plastic and Reconstructive Surgery” This study demonstrated that multipotential cells grafted onto matrices successfully grew new hair in 92% of mice, suggesting potential future applications in hair restoration using this method.
This article reviews the role of the hairless protein in hair cycling and gene regulation, noting the need for further understanding of its JmjC domain and subcellular localization roles.
January 2007 in “Elsevier eBooks” This article describes the anatomy and life cycle of hair follicles, explaining how disruptions in the hair growth cycle can lead to various forms of alopecia.
January 2006 in “Advances in developmental biology” This review discusses the roles of the hairless (HR) protein as a corepressor, particularly its impact on RORα-mediated transcriptional repression, and reports no new experimental findings.
December 2005 in “Journal of Marine Fisheries” This review discusses the causes and patterns of telogen effluvium and reports no new clinical findings; it highlights spontaneous recovery in many cases despite severe hair loss.
December 2005 in “Journal of Marine Fisheries” This article reviews telogen effluvium, including its causes, presentation, and prognosis, and concludes that while chronic cases may be severe, spontaneous recovery can often occur after many years.
January 2004 in “Giornale di Metafisica: revista bimestrale di filosofia” This study suggests that increased Wnt signaling may promote excessive differentiation of melanocytes, leading to exhaustion of melanocyte stem cells and hair graying in aged mice.
April 2003 in “Experimental Dermatology” This workshop review from the Australian Hair and Wool Research Society discusses findings in cutaneous biology and endocrinology but presents no new research results.
December 1963 in “Medical Entomology and Zoology” This study found that Wnt1a overexpression from bone marrow mesenchymal stem cells enhanced hair follicle regeneration in mice by promoting the dermal papilla's role in hair cycling and gene expression recovery.
June 2022 in “South Florida Journal of Health” This review discusses Scalp Threading as a promising treatment for androgenic alopecia, with hair growth results comparable to multiple applications of minoxidil, but reports no new clinical results.
42 citations
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March 2008 in “Molecular and Cellular Endocrinology” This review explores the potential (neuro-)endocrine influences on hair follicle epithelial stem cell biology and emphasizes the need for more systematic research, but it provides no new empirical results.
11 citations
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November 2021 in “JBMR plus” This review discusses the role of the unliganded vitamin D receptor in hair follicle cycling and tumor formation in mice and reports no new experimental findings.
1 citations
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September 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that miR-148a plays a significant role in regulating skin homeostasis and hair follicle cycling, influencing stem cell activity and development in mice.
854 citations
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February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” This review summarizes recent advances in understanding the molecular mechanisms of hair follicle formation and discusses potential future clinical applications for treating hair loss and skin tumors, but it reports no new clinical results.
236 citations
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July 2001 in “Trends in Molecular Medicine” This review discusses common hair loss conditions and explores how advancements in hair follicle biology might lead to more effective treatments but reports no new results.
224 citations
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March 2006 in “Seminars in Cutaneous Medicine and Surgery” This article discusses the hair follicle's regenerative cycles and the molecular mechanisms influencing them, emphasizing the need for therapeutic targeting of the "hair cycle clock" to manage hair growth disorders, without reporting new research findings.
222 citations
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January 2005 in “Endocrine journal” This article discusses the potential role of melatonin in protecting skin against stress and maintaining homeostasis, based on its local synthesis and various protective functions, but presents no new clinical results.
199 citations
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April 2010 in “Nature” A gene called APCDD1, which controls hair growth, is found to be faulty in a type of hair loss called hereditary hypotrichosis simplex.
186 citations
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December 2012 in “Current opinion in cell biology” This review discusses the recent advancements in understanding how keratins influence cytoarchitecture, cell dynamics, and disease processes but reports no new clinical results; the authors highlight its roles in development and diseases like cancer.
185 citations
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January 2010 in “Experimental Dermatology” This study introduces the concept of a "gut–brain–skin axis" where ingesting a specific Lactobacillus strain in mice may reduce stress-induced skin inflammation and hair growth inhibition.