TLDR Wnt1a from stem cells boosts hair growth and regeneration in mice.
This study investigates the impact of bone marrow mesenchymal stem cell (BM-MSC) overexpression of Wnt1a on hair follicle regeneration in mice. The findings indicate that Wnt-conditioned medium (Wnt-CM) accelerates the transition of hair follicles from the telogen to anagen phase and enhances alkaline phosphatase (ALP) expression in the dermal papilla (DP) area. Additionally, Wnt-CM treatment upregulates hair induction-related genes and restores DP cell gene expression affected by dihydrotestosterone. The study concludes that BM-MSC-generated Wnt1a enhances the DP's capacity to induce hair cycling and regeneration.
1 citations
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October 2011 in “PubMed” Teen hair loss is common, can be caused by genetics or health issues, and can be diagnosed and treated.
61 citations
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June 2014 in “Scientific Reports” Wnt1a-conditioned medium from stem cells helps activate cells important for hair growth and can promote hair regrowth.
June 2025 in “Stem Cell Research & Therapy” Understanding hair growth pathways can lead to better hair loss treatments.
31 citations
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August 2021 in “Stem Cell Research & Therapy” The conclusion is that understanding how hair follicle stem cells live or die is important for maintaining healthy tissue and repairing injuries, and could help treat hair loss, but there are still challenges to overcome.
October 2025 in “Cell Transplantation” New hair loss treatments like stem cells and gene therapy show promise but need more research for safety and effectiveness.
35 citations
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January 2020 in “Skin Pharmacology and Physiology” The review concluded that keeping the hair-growing ability of human dermal papilla cells is key for hair development and growth.