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research Matrix matching in quantitative bioanalysis by LC–MS/MS a dream or a reality?
This article reviews analysis techniques in LC-MS/MS and discusses the potential use of a novel in-sample calibration curve method, but reports no new experimental results.
research Anabolic-androgenic steroids. Mechanism of action and clinical effects
This study provides a comprehensive analysis of anabolic-androgenic steroids, reporting that their use enhances muscle mass but is associated with significant health issues including cardiac muscle hypertrophy, liver disease, and changes in gender characteristics, emphasizing the need for patient awareness of these risks.
research ISID1343 - Efficacy of asymmetric siRNA targeting androgen receptor for the treatment of androgenetic alopecia
This study found that a cholesterol-conjugated, cell-penetrating asiRNA targeting the androgen receptor effectively reduced hair loss and promoted hair growth in mouse models of androgenetic alopecia, suggesting potential as a novel treatment.
research Advancing Hair Loss Assessment in Alopecia Areata: The Mathematical Case for Centralised, Standardised Imaging
In this study, centralised measurements provided more consistent and accurate results for assessing hair loss in mild-to-moderate alopecia areata, reducing error compared to local ratings.
research Enhanced viability and neural differential potential in poor post-thaw hADSCs by agarose multi-well dishes and spheroid culture
This study found that forming spheroids using silicone micro-wells improved the viability and neural differentiation potential of human adipose-derived stem cells after thawing.
research A case of encephalocraniocutaneous lipomatosis
This case report describes a young man diagnosed with encephalocraniocutaneous lipomatosis who had unique bilateral optic disc colobomas, a previously unreported association with this syndrome.
research Polysulfonic acid mucopolysaccharide exerts anti scarring effect in rats through modulation of TGF β 1/Smad signaling pathway
This study found that polysulfonic acid mucopolysaccharide may reduce skin scarring in rats by influencing the TGF-β1/Smad signaling pathway.
research Adipose-derived stem cell exosomes promote critical-sized bone defect repair by enhancing the homing of bone marrow mesenchymal stem cells
This study observed that exosomes derived from adipose-derived stem cells significantly enhanced bone marrow mesenchymal stem cell migration and osteogenesis, leading to improved bone regeneration in a rat model of calvarial defects.
research The polygenic architecture of hidradenitis suppurativa reveals signaling mechanisms that implicate epithelial remodeling
In a human genetic study on hidradenitis suppurativa, researchers identified 12 genetic risk loci and found that CXCR4-CD74 signaling may play a key role in hair follicle inflammation, suggesting CXCR4 blockade as a potential therapeutic approach for this condition.
research M-CSF-Stimulated CD11b+ Myeloid Cells Induce Alopecia Areata in C3H/HeJ Mice
This study found that dermal injection of M-CSF stimulated CD11b + myeloid cells can induce alopecia areata in mice by potentially activating B lymphocytes, offering insight into the disease's pathogenesis.
research Saccharomyces cerevisiae BLYAS, a New Bioluminescent Bioreporter for Detection of Androgenic Compounds
This study engineered a bioluminescent yeast strain responsive to androgenic chemicals, demonstrating rapid and sensitive detection suitable for high-throughput screening and environmental monitoring.
research Analysis of post-COVID symptoms and predisposing factors for chronic post-COVID syndrome
This study identified female sex and specific radiological findings as risk factors for chronic post-COVID syndrome, while long-term use of angiotensin-2 receptor blockers was linked to fewer chronic symptoms.
research Premature Desquamation of the Inner Root Sheath in Noninflamed Hair Follicles as a Specific Marker for Central Centrifugal Cicatricial Alopecia
This study found that the presence of premature desquamation of the inner root sheath in noninflamed hair follicles is a relatively specific marker for diagnosing central centrifugal cicatricial alopecia.
research Efficacy and Safety Evaluation of Sesa oil and Sesa Capsule In Different Hair Disorders
This study found that SESA oil and capsules were associated with decreased hair fall and increased hair regeneration in patients with alopecia, without any reported adverse reactions over three months.
research 1343 Efficacy of asymmetric siRNA targeting androgen receptor for the treatment of androgenetic alopecia
This study found that intradermal injection of a specially designed RNA molecule, cp-asiAR, successfully reduced androgen receptor levels and promoted hair growth in a mouse model of androgenetic alopecia, while also improving hair follicle characteristics in ex vivo human scalp tissues without significant toxicity.
research Adipose-derived stromal cell in regenerative medicine: A review
This review discusses the potential applications of adipose-derived stromal cells for treating conditions like colitis, liver failure, and more, without presenting new clinical results.
research Scalp psoriasis associated with central centrifugal cicatricial alopecia
This case report describes a rare instance where scalp psoriasis mimicked severe alopecia, initially misdiagnosed as central centrifugal cicatricial alopecia.
research Twins with psychiatric features and a nonsense HRAS variant affecting transcript processing
In this study, researchers observed that twins with a novel de novo nonsense variant in HRAS exhibited distinctive features, including neuropsychiatric symptoms, potentially indicating a wider clinical spectrum for conditions known as RASopathies.
research Derivation and Validation of Systemic Lupus International Collaborating Clinics Classification Criteria for Systemic Lupus Erythematosus
This article discusses revised SLE classification criteria by the SLICC and reports no new research results.
research WHEN SILENCE TAKES OVER: A CASE OF CATATONIC SYNDROME REVEALING SYSTEMIC LUPUS ERYTHEMATOSUS
This case report describes a 21-year-old woman whose catatonia led to the diagnosis of systemic lupus erythematosus, suggesting catatonia may be an underrecognized manifestation of neuropsychiatric lupus.
research SEASONAL DERMATOPATHY AND CONCURRENT REPRODUCTIVE FINDINGS IN CAPTIVE FOSSA (CRYPTOPROCTA FEROX)
This study proposes that seasonal alopecia and reproductive changes in six female fossas at the San Diego Zoo may be linked to hormonal changes associated with reproductive activity.
research Hair regeneration using adipose-derived stem cells.
This review discusses the potential and limitations of adipose-derived stem cells and their conditioned medium for hair regeneration, highlighting novel preconditioning methods to enhance their effectiveness, without presenting new clinical results.
research Limited stage small cell lung cancer
Treat limited stage small cell lung cancer with chemotherapy and radiation, and consider preventive brain radiation for better survival chances.
research Efficacy of modern methods for assessing the severity of alopecia areata
This study found that the SBN system effectively evaluates and describes the severity and clinical variant of alopecia areata using a standardized scale, aiding in patient management and disease course prediction.
research Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus
This study found that the new SLICC classification criteria for systemic lupus erythematosus were more sensitive and resulted in fewer misclassifications than the current ACR criteria, although they had lower specificity.
research 022 Randomized, double-blind, placebo-controlled, single-centre, phase I safety study of intradermal injections of autologous fibroblasts isolated from the non-bulbar dermal sheath of the hair follicle to treat skin aging
RCS-01 is safe and may help rejuvenate aging skin.
research Hair Analysis Provides a Historical Record of Cortisol Levels in Cushing's Syndrome
This study found that hair cortisol levels were significantly higher in patients with Cushing's Syndrome compared to healthy controls, suggesting hair analysis can provide historical information on cortisol exposure.
research Patient satisfaction with multidisciplinary shared medical appointments for alopecia areata and frontal fibrosing alopecia
This study reported high patient satisfaction with multidisciplinary shared medical appointments for alopecia areata and frontal fibrosing alopecia, with participants appreciating the educational and supportive group environment.
research Lentiviral Arrays for Live-cell Dynamic Monitoring of Gene and Pathway Activity During Stem Cell Differentiation
This study found that a lentiviral array of reporters can identify lineage-specific promoters and pathways in mesenchymal stem cell differentiation, aiding in the prediction of signaling pathway effects.