374 citations
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May 2016 in “The Lancet. Diabetes & endocrinology” This article reviews the clinical complications and increased mortality risks associated with Cushing's syndrome but does not present new clinical data; it emphasizes the need for prompt treatment to mitigate these risks.
217 citations
,
July 2009 in “Experimental and Clinical Endocrinology & Diabetes” This study found that hair cortisol levels were significantly higher in patients with Cushing's Syndrome compared to healthy controls, suggesting hair analysis can provide historical information on cortisol exposure.
42 citations
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November 2019 in “Frontiers in Endocrinology” This article provides an overview of diagnosing Cushing's syndrome, emphasizing the importance of assessing clinical signs and the appropriate use of first-line biochemical screening.
42 citations
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January 2007 in “Pediatric dermatology” This report describes an 11-year-old boy with Netherton syndrome who developed Cushing syndrome after using low-potency hydrocortisone ointment extensively, highlighting caution with long-term topical treatments in such conditions.
37 citations
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September 2002 in “Acta pædiatrica” In this study, a patient with cystic fibrosis developed iatrogenic Cushing's syndrome due to impaired clearance of budesonide from concurrent itraconazole use, highlighting the need for regular monitoring in such combination therapies.
25 citations
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January 1978 in “JAMA” This case report describes a 45-year-old woman who developed Cushing's syndrome and hirsutism after using topically applied desoximetasone (Topicorte).
23 citations
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February 1979 in “Veterinary Clinics of North America: Small Animal Practice” This review discusses the physicochemical properties, binding mechanisms, and factors affecting corticosteroid-binding globulin (CBG) functions, but reports no new clinical results.
22 citations
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February 2010 in “The Veterinary clinics of North America. Small animal practice/Veterinary clinics of North America. Small animal practice” This article reviews the evidence regarding the role of sex hormones in occult hyperadrenocorticism and reports no new findings, highlighting the unproven nature of their involvement.
11 citations
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October 2003 in “Postgraduate Medical Journal” This study described four cases of delayed diagnosis of Cushing’s syndrome, highlighting that increased clinical awareness and screening could reduce its associated morbidity and mortality.
10 citations
,
December 1992 in “PubMed” This report of three cases found that diagnosing hypercortisolism during pregnancy can be challenging, but early detection using unbound steroid levels and MRI could prevent severe complications.
9 citations
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April 2020 in “Endocrinology, diabetes & metabolism case reports” This case study highlights the significance of early diagnosis and treatment of Cushing's syndrome during pregnancy, as it is associated with severe maternal and fetal complications, including stillbirth.
6 citations
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February 2017 in “Case Reports in Dermatology” This case report highlights that hair loss, though common in the general population, may be a rare presenting symptom of Cushing's disease, as observed in a woman with multiple dermatological signs of the condition.
6 citations
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September 2002 in “Acta pædiatrica” This case study observed that long-term itraconazole and budesonide use in a cystic fibrosis patient led to iatrogenic Cushing's syndrome due to inhibited metabolic clearance of budesonide, suggesting a need for regular adrenal insufficiency monitoring in such treatments.
5 citations
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February 2023 in “European journal of endocrinology” This study found that older patients with Cushing's syndrome had fewer typical symptoms of hypercortisolism, more comorbidities, and were more often treated conservatively compared to younger patients.
5 citations
,
May 2008 in “Annals of saudi medicine/Annals of Saudi medicine” This case report from India observed that short-term cabergoline treatment brought clinical and biochemical remission in a 12-year-old with persistent Cushing disease after surgery and radiotherapy.
4 citations
,
November 2021 in “Frontiers in endocrinology” This study systematically compared pediatric and adult Cushing's disease patients, revealing more severe and earlier-onset symptoms in males, and distinct gender-specific clinical manifestations.
4 citations
,
March 2013 in “Neuropsychiatric Disease and Treatment” This case report describes a rare instance of a patient with anorexia nervosa who was subsequently diagnosed with Cushing's syndrome, highlighting diagnostic challenges due to overlapping symptoms.
3 citations
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January 2017 in “Journal of clinical and diagnostic research” This case series reported incidents of iatrogenic Cushing's Syndrome linked to high doses of intralesional corticosteroid injections and mesotherapy regimens, highlighting the need for cautious prescription practices and further research on mesotherapy safety.
2 citations
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March 2018 in “INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY” This case report describes a pregnant woman diagnosed with Cushing Syndrome, likely due to an adrenal tumor, whose condition worsened during hospitalization, resulting in heart failure, sepsis, and shock.
2 citations
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January 2001 in “Humana Press eBooks” This review explores pseudo-Cushing's states that mimic Cushing's syndrome but do not involve elevated cortisol, and it presents no new research findings.
1 citations
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July 2024 in “International Journal of Innovative Science and Research Technology (IJISRT)” In this case report, a 36-year-old woman was diagnosed with iatrogenic Cushing Syndrome caused by topical steroid use, leading to skin ulcers, diabetes, and anemia. Her condition improved after discontinuing the steroids and receiving appropriate treatment.
1 citations
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October 2023 in “BMC oral health” This study reported that while Intralesional Triamcinolone Acetonide injections effectively improved mouth opening in patients with Oral Submucous Fibrosis, it also led to symptoms of Cushing's Syndrome, highlighting the need for careful monitoring of adverse effects.
1 citations
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October 2023 in “Journal of the Endocrine Society” In this case report, researchers highlight a 57-year-old HIV patient on ritonavir who developed Cushing’s syndrome from over-the-counter intranasal fluticasone, underscoring the risks of drug interactions and the importance of counseling patients about potential steroid ingredients in OTC products.
1 citations
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May 2021 in “Journal of the Endocrine Society” This case report describes a woman with HIV who developed iatrogenic Cushing syndrome and adrenal insufficiency due to the interaction between fluticasone and ritonavir, highlighting the need for careful management of corticosteroid use in patients on protease inhibitors.
1 citations
,
January 2018 in “Cogent Medicine” This case study reports a pregnant woman with bullous pemphigoid who developed Cushing syndrome following steroid treatment, emphasizing the need for careful management of steroid-related complications.
1 citations
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November 2013 This study identified hypogonadism in 65% of men with Cushing syndrome, suggesting glucocorticoid excess may affect the hypothalamic-pituitary level or testosterone metabolism.
This source explains that Equine Cushing’s disease, or PPID, in horses is due to the degeneration of brain cells producing dopamine, leading to elevated cortisol levels and characteristic symptoms; it outlines diagnosis methods and emphasizes life-long pergolide treatment to manage the condition.
January 2026 in “JCEM Case Reports” This case report presents a rare instance of recurrent ACTH-independent Cushing’s syndrome due to PBMAH, coinciding with the development of a pheochromocytoma, highlighting the need for thorough reevaluation in similar recurring cases.
October 2025 in “Journal of the Endocrine Society” This case report describes a 35-year-old woman with a Rathke’s cleft cyst presenting with Cushing disease, highlighting the need to evaluate hormonal hypersecretion in atypical pituitary lesions.
October 2025 in “Journal of the Endocrine Society” In this case study, a 69-year-old woman with severe hypercortisolism developed acute adrenal insufficiency after starting ketoconazole treatment, highlighting the need for cautious dosing and close monitoring of adrenal function, particularly in patients with prior glucocorticoid exposure.