Cushing Syndrome During Pregnancy: New Diagnostic Methods Used in Three Cases of Adrenal Cortex Carcinoma

    December 1992 in “ PubMed ”
    L Billaud, Sanson Ml, B Guilhaume, Xavier Bertagna, Abecassis Jp, Luton Jp
    TLDR Early detection of Cushing's syndrome during pregnancy is crucial to prevent severe complications.
    The document reported on three cases of adrenal cortex carcinoma causing Cushing's syndrome during pregnancy, diagnosed after 24, 27, and 28 weeks of amenorrhea. The condition was revealed by local tumoral signs in two cases and pulmonary embolism in the third. Clinical features of hypercortisolism, such as moderate hair growth and weight gain, were initially attributed to pregnancy. Diagnosis was confirmed by elevated urinary and salivary cortisol levels and increased salivary testosterone levels, with MRI showing unilateral adrenal masses. The study highlighted the diagnostic challenges of hypercortisolism during pregnancy and emphasized the importance of assessing unbound steroids and using MRI for early diagnosis to prevent severe complications.
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