TLDR Men with low testosterone or breast growth should be checked for Cushing syndrome.
In a study of 37 males with Cushing syndrome (CS), researchers found that 65% experienced hypogonadism, characterized by decreased libido and erectile dysfunction, with 67.5% having low testosterone levels (<3 ng/ml). Gynecomastia was observed in 18.9% of participants. The study indicated that glucocorticoid excess in CS likely affected the hypothalamic-pituitary level, as suggested by hormonal assessments, although increased testosterone degradation or inhibition of testis receptors could not be excluded. The findings suggested that men with hypogonadism and/or gynecomastia should be evaluated for CS.
January 2013 in “Journal of Endocrinology and Diabetes Mellitus” Cushing syndrome often causes low testosterone and sexual issues in men.
April 2024 in “JCEM case reports” A woman's rare benign tumor that released both cortisol and testosterone was successfully removed, improving her health.
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March 2011 in “Infertility” Hormone imbalances from the pituitary, thyroid, and adrenal glands can cause infertility, but treating these disorders can improve fertility.
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July 1988 in “Journal of The American Academy of Dermatology” Hormone imbalances can cause specific skin changes, which may help in early detection of endocrine disorders.
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November 2011 in “InTech eBooks” Most adrenal cortex tumors are benign and non-secreting, but proper diagnosis and treatment are important due to the rare possibility of cancer.