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    Did you mean Hypothalamic-Pituitary-Adrenal Axis?
    Glossary Hypothalamic-Pituitary-Adrenal Axis

    regulates stress response through hormone release from brain and adrenal glands

    The Hypothalamic-Pituitary-Adrenal (HPA) Axis is a complex network involving the hypothalamus, pituitary gland, and adrenal glands, which work together to regulate the body's response to stress. When you encounter stress, the hypothalamus releases corticotropin-releasing hormone (CRH), prompting the pituitary gland to secrete adrenocorticotropic hormone (ACTH), which in turn stimulates the adrenal glands to produce cortisol, a key stress hormone. This system plays a crucial role in maintaining homeostasis and can impact various bodily functions, including immune response and metabolism.

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    1. Physiology of the Hypothalamic Pituitary Gonadal Axis in the Male Urologic Clinics of North America · 2016 · 70 citations
    2. Faculty Opinions recommendation of Hair cortisol levels as a retrospective marker of hypothalamic-pituitary axis activity throughout pregnancy: comparison to salivary cortisol. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2011
    3. Sex differences in the hypothalamic–pituitary–adrenal axis’ response to stress: an important role for gonadal hormones Neuropsychopharmacology · 2019 · 197 citations
    4. Expression of Hypothalamic–Pituitary–Thyroid Axis RelatedGenes in the Human Skin Journal of Investigative Dermatology · 2002 · 155 citations
    5. Hypothalamic–Pituitary–Thyroid Axis Hormones Stimulate Mitochondrial Function and Biogenesis in Human Hair Follicles Journal of Investigative Dermatology · 2013 · 95 citations
    6. Hair loss and hypothalamic-pituitary-adrenocortical axis activity in captive rhesus macaques (Macaca mulatta). PubMed · 2014 · 28 citations
    7. The local hypothalamic–pituitary–adrenal axis in cultured human dermal papilla cells BMC Molecular and Cell Biology · 2020 · 9 citations
    8. The human hair follicle has established a fully functional peripheral equivalent of the hypothamalic‐pituitary‐adrenal‐axis (HPA) Experimental Dermatology · 2005 · 9 citations
    9. Qiviut cortisol reflects hypothalamic–pituitary–adrenal axis activity in muskoxen (Ovibos moschatus) General and comparative endocrinology · 2021 · 7 citations
    10. Involvement of the central hypothalamic-pituitary-adrenal axis in hair growth and melanogenesis among different mouse strains PLoS ONE · 2018 · 6 citations
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    Community 1 of 3

    1. Mechanism of action of alfatradiol (17 alpha estradiol) Reddit · 29 May 2024
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