Cushing's Syndrome Complicating Pemphigoid Gestationis

    January 2018 in “ Cogent Medicine
    Olga Yu. Olisova, N.P. Tepljuk, Amal Hubail, Rosa Belkharoeva, Olga V. Grabovskaya, Vladimir Pinegin
    TLDR Careful management of steroid use is crucial in pregnant women with bullous pemphigoid to avoid complications like Cushing syndrome.
    The document described a case study of a 23-year-old pregnant woman with pemphigoid gestationis complicated by Cushing syndrome due to steroid treatment. Despite initial steroid therapy, her condition worsened postpartum, leading to severe complications like osteoporosis and Cushing syndrome. Adjustments in treatment, including reducing steroid doses and adding medications like Dapson and azathioprine, eventually improved her condition. The study emphasized the need for careful steroid management in treating bullous pemphigoid during pregnancy to avoid severe side effects, continuous monitoring, and patient education on the risks and benefits of steroid therapy. It also called for further research on managing severe BP and CS, especially in pregnant women, and highlighted the potential benefits of a multidisciplinary approach.
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