Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This case study observed that long-term itraconazole and budesonide use in a cystic fibrosis patient led to iatrogenic Cushing's syndrome due to inhibited metabolic clearance of budesonide, suggesting a need for regular adrenal insufficiency monitoring in such treatments.

This review discusses the pharmacological properties and therapeutic potential of K+ channel opening compounds, noting their prospective use in treating cardiovascular and respiratory conditions, but reports no new results.

Nanocrystals improve alopecia areata treatment by better targeting hair follicles.

This study reports that α-casein in bovine milk can form stable complexes with zinc, potentially useful for fortifying milk-based products to enhance zinc availability.

This study discusses that permanent hair straightening can be achieved at neutral or acidic pH conditions, with varying effects on cystine and lanthionine levels, by inducing supercontraction of the hair fiber.

This study found that several preservatives, including triclocarban and triclosan, showed potential endocrine-disrupting effects on various nuclear receptors in both in silico and in vitro models.

This study suggests that antihepcidin antibodies may effectively treat inflammatory anemia by manipulating iron metabolism, based on experiments conducted in mouse models and hHepc knock-in mice.

This study found that cromakalim and pinacidil significantly inhibited porcine detrusor muscle contractions, suggesting these ATP-sensitive potassium channel openers may have potential in treating certain bladder diseases.

This study found that minoxidil sulfate stimulates Cl channels, potentially depolarization-activated and outwardly rectifying, in eccrine clear cells, while minoxidil itself stimulates Ca-insensitive K currents.

This study found that cooling combined with antioxidants can improve scalp cooling effectiveness in preventing chemotherapy-induced alopecia by maintaining hair follicle viability and function.

This phase I study reported that ETC-159, targeting Wnt signalling, showed tolerable safety profiles at doses that inhibit its pathway, though bone turnover markers increased, warranting early and regular monitoring. No tumor responses were observed, but two patients achieved stable disease for several cycles.

This study observed that intramuscular injection of sodium 131iodide at doses of up to 1 mCi can successfully induce hypothyroidism in rats without significantly damaging muscle or nearby tissues, despite concerns of adverse effects.

This study found that lysine carboxymethyl cysteinate helps protect the epidermis from UVB-induced damage by activating autophagy and restoring cornification processes in a skin model.

This case report describes an 80-year-old man who developed valproate toxicity and functional decline after starting isoniazid, highlighting a potential drug interaction in elderly patients.

In this study, cetirizine hydrochloride was formulated into niosomal and cubosomal gels, showing potential for off-label use in treating androgenic alopecia due to effective skin permeation and acceptable safety profiles; cubosomal gels exhibited superior permeation compared to niosomal gels.

This case report detailed a 38-year-old woman with thallium intoxication, who initially presented with polyneuropathy and alopecia. The diagnosis was confirmed by toxicology, and treatment with potassium hexacyanoferrate led to full recovery, underscoring the importance of early diagnosis and treatment in toxic polyneuropathies.

This study examined the vasorelaxant effects of two similar alkaloids, chloroquine and cinchonine, in a model of smooth muscle contractions induced by phenylephrine. Results are not reported in the abstract.

This study reports the development of a novel protocol to purify human TRPV3 ion channels, revealing functional properties and differences in ligand interactions, enabling further structural and functional research.

This study found that baricitinib can counteract the cytokine-driven reduction of the enzyme PADI1 in human keratinocytes, which may help improve skin barrier function in atopic dermatitis by enabling epidermal differentiation.

This study concluded that chitosan nanoparticles loaded with minoxidil effectively target hair follicles and reduce dermal exposure compared to iontophoresis, despite similar drug delivery potential to the follicles.

In this study, all stereoisomers of cyoctol were synthesized and tested, revealing that contrary to initial patent claims, cyoctol does not function as an anti-androgen.

The researchers reported that in a mouse model of alopecia areata, tofacitinib treatment influenced disease progression by modulating CD8⁺ T cell infiltration through the linoleic acid metabolism and magnesium ion pathway, offering insights into potential treatment approaches.

Minoxidil sulfate, delivered through iontophoresis, can be used to treat hair loss.

In this study, ozenoxacin was found to inhibit sebum production in insulin- and 5α-DHT-differentiated hamster sebocytes in a dose-dependent manner, suggesting potential benefits in acne management by combining antimicrobial activity against C. acnes with reduced sebum production.

This study developed two sensitive spectrophotometric methods to accurately determine finasteride in pure and tablet forms, demonstrating linear response and compliance with ICH guidelines.

This study suggests that a biomaterial-based approach using microneedles and ion solutions to deliver SiO3 2− ions may disrupt inflammatory cycles and improve outcomes in inflammatory dilated cardiomyopathy (iDCM).

Baricitinib may reactivate trichilemmal cysts in people with a history of these cysts.

This article discusses the potential for combining PROTACs with other therapeutic modalities in drug discovery and reports no clinical results.

This study suggests that reversible hypopigmentation in homocystinuric patients may result from tyrosinase inhibition by homocyst(e)ine, with in-vitro experiments showing copper sulfate reversing this inhibition.

This study found that several newly synthesized dihydrobenzopyran compounds inhibited insulin secretion and had vasorelaxant activity, with some more potent than reference KATP channel activators, though compound 21 functioned as a Ca2+ entry blocker.