Sensitive Bromatometric Determination of Finasteride in Pharmaceuticals Based on Complex-Formation Reactions
January 2006
in “
Analytical chemistry, an Indian journal
”
TLDR Two accurate methods were developed to measure finasteride in tablets.
Two sensitive spectrophotometric methods were developed for determining finasteride in pure and tablet forms, based on bromination and subsequent redox-complexation reactions. Method A involved measuring iron (III) complexed with thiocyanate at 470 nm, while Method B measured iron (II) complexed with orthophenanthroline at 510 nm. Both methods showed strong linear relationships with finasteride concentration, obeying Beer’s law within specified ranges. The methods demonstrated high accuracy and precision, with results aligning closely with label claims and a reference method. Excipients did not interfere, and recovery tests confirmed the methods' accuracy.
