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    Glossary Corneal Epithelium

    outermost cell layer of the eye's clear front surface

    The corneal epithelium is the outermost layer of the cornea, which is the clear, dome-shaped surface that covers the front of the eye. This thin, protective layer of cells helps to shield the eye from dust, debris, and bacteria, while also playing a crucial role in maintaining clear vision by providing a smooth surface for light to enter the eye.

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    Research 30 of 1000+

    1. Corneal Limbal Microenvironment Can Induce Transdifferentiation of Hair Follicle Stem Cells into Corneal Epithelial-like Cells Stem Cells · 2008 · 162 citations
    2. Transdifferentiation of corneal epithelium into epidermis occurs by means of a multistep process triggered by dermal developmental signals Proceedings of the National Academy of Sciences · 2005 · 130 citations
    3. Transdifferentiation of corneal epithelium: evidence for a linkage between the segregation of epidermal stem cells and the induction of hair follicles during embryogenesis. The International Journal of Developmental Biology · 2004 · 55 citations
    4. 1378 Identification of two distinct stem cell clusters, Lrig1-derived and Wnt/CD44-dependent, in corneal epithelium Journal of Investigative Dermatology · 2018
    5. 09-P006 Epithelial–mesenchymal interactions promote hair follicle neogenesis and a new stem cell niche in adult corneal epithelium Mechanisms of Development · 2009
    6. Network analysis reveals potential mechanisms that determine the cellular identity of keratinocytes and corneal epithelial cells through the Hox/Gtl2-Dio3 miRNA axis Frontiers in Cell and Developmental Biology · 2025
    7. Corneal epithelial‐like transdifferentiation of hair follicle stem cells is mediated by pax6 and β‐catenin/Lef‐1 Cell Biology International · 2009 · 20 citations
    8. Limbal microenvironment can induce transdifferentiation of hair follicle stem cells into corneal epithelial‐like cells Acta Ophthalmologica · 2008
    9. Homeostatic maintenance of the murine corneal epithelium in pathophysiological contexts Työväentutkimus Vuosikirja · 2020
    10. Wnt7a can up-regulates cell adhesion related protein fibronectin expression and promotes cell proliferation in corneal epithelial cells 2023
    11. Transdifferentiation of rat hair follicle stem cells to epithelium-like cells induced by stroma of limbus corneae Di-san junyi daxue xuebao · 2008
    12. Insulin Promotes Corneal Nerve Repair and Wound Healing in Type 1 Diabetic Mice by Enhancing Wnt/β-Catenin Signaling American Journal of Pathology · 2020 · 15 citations
    13. Murine Hair Follicle Derived Stem Cell Transplantation onto the Cornea Using a Fibrin Carrier BIO-PROTOCOL · 2018 · 3 citations
    14. Le tégument des vertèbres et la spécification de l'épithélium cornéen HAL (Le Centre pour la Communication Scientifique Directe) · 2010
    15. Thymosin β4 promote the wound healing of cornea 2010
    16. Regeneration of Epidermal and Dental Tissues, Lens and Cornea Elsevier eBooks · 2006
    17. From Hair to Cornea: Toward the Therapeutic Use of Hair Follicle-Derived Stem Cells in the Treatment of Limbal Stem Cell Deficiency Stem Cells · 2010 · 135 citations
    18. Spheroid transplantable and functional retinal pigment epithelium derived from non-colony dissociated human induced pluripotent stem cells Research Square (Research Square) · 2020
    19. Meibomian gland changes in the rhino (hrrhhrrh) mouse. PubMed · 1988 · 48 citations
    20. Topical Spironolactone in the Treatment of Ocular Graft-Versus-Host Disease Curēus · 2023 · 2 citations
    21. 1377 Decoding frontal fibrosing alopecia and lichen planopilaris: Macrophages hold the key? Journal of Investigative Dermatology · 2018
    22. 1379 Cell of origin contributes to the melanoma diversity Journal of Investigative Dermatology · 2018
    23. Aged differentiated cells reverse into native stemness-like state by niche cytokines to sustain lifelong homeostasis and tissue repair Nature Communications · 2026
    24. Platelet-Rich Plasma and Combination Therapies for Dry Eye Disease: Current Advances and Future Directions Transfusion Medicine and Hemotherapy · 2025 · 1 citations
    25. 1433 Role of BNC1 in keratinocytes proliferation and migration: A critical regulator of wound healing? Journal of Investigative Dermatology · 2018
    26. Keratin disorders: from gene to therapy 2011 · 109 citations
    27. The Potential Reversible Transition between Stem Cells and Transient-Amplifying Cells: The Limbal Epithelial Stem Cell Perspective Cells · 2024 · 1 citations
    28. Keratin expression by corneal and limbal stem cells during development 2020 · 25 citations
    29. Lineage potential, plasticity and environmental reprogramming of epithelial stem/progenitor cells Biochemical Society Transactions · 2014 · 4 citations
    30. Tp63-expressing adult epithelial stem cells cross lineages boundaries revealing latent hairy skin competence Nature Communications · 2020 · 8 citations