18 citations
,
October 2016 in “European Journal of Pharmaceutics and Biopharmaceutics” In this study, FITC-labeled BSA nanocarriers delivered a model drug deeper into porcine ear skin hair follicles than the carriers themselves, as shown by confocal microscopy.
2 citations
,
December 2023 in “International journal of molecular sciences” This study reviews the complex keratinization process in the epidermis, detailing how various factors regulate keratinocyte differentiation and emphasizing the importance of understanding this process for the pathogenesis of skin disorders like ichthyoses and psoriasis.
November 2024 in “Stem Cell Research & Therapy” A new method improves the isolation of hair follicle cells for better hair growth research.
This study found that new methods for isolating human dermal papilla cells were more efficient than traditional methods, maintaining higher levels of specific markers and improving the cells' research potential.
In this study, researchers developed a method using stencils to create controlled stiffness gradients in alginate hydrogels, revealing that stiffer regions within the gels promote deeper invasion by breast cancer cells, facilitating the study of mechanosensitive cellular behaviors.
200 citations
,
November 1997 in “Planta” This study found that while a tip-focused calcium gradient influences localized growth in root hairs and pollen tubes, it is not the primary determinant of growth direction in root hairs of Arabidopsis thaliana.
69 citations
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March 2003 in “Journal of Experimental Botany” This study found that salinity stress in Arabidopsis thaliana root hairs may inhibit hair extension through changes in the tip-focused Ca(2+) gradient, while cytosolic pH remains unaffected.
25 citations
,
May 2006 in “Annals of Botany” This study suggests that a tip-focused gradient of intracellular G-actin concentration at the apex is crucial for root hair growth, and maintaining this gradient requires high calcium levels at the root hair tips.
This study found that a data-driven model using XGBoost effectively predicts individualized responses to minoxidil for androgenetic alopecia, outperforming traditional methods in accuracy and reliability.
January 2014 in “China Surfactant Detergent & Cosmetics” This study established a method using reversed-phase high performance liquid chromatography to determine finasteride concentration in hair cosmetics, showing a strong linear relationship with mass concentration and recoveries between 90.3% and 102.0%.
10 citations
,
January 1980 in “Ultrastructural pathology” This study suggests that elevated copper levels in domestic tapwater, exacerbated by its aggressive properties, likely contribute to green hair by damaging the cuticle and increasing copper uptake.
61 citations
,
May 2014 in “International journal of pharmaceutics” This research describes a process for producing caffeine nanocrystals, which may enhance skin penetration by accumulating in hair follicles and maintaining stability for two months, paving the way for in vivo testing.
January 2020 in “International Journal of Research in Pharmacy and Chemistry” This study developed a validated HPLC method for accurately estimating dutasteride and its related compounds in capsules, suitable for routine and stability sample analysis.
30 citations
,
July 1998 in “British Journal of Dermatology” This study found that in a rat skin model, fat cells inhibited the proliferation of organoid hair follicle cells and fibroblasts but may have accelerated hair follicle cell differentiation.
January 2018 in “Refubium (Universitätsbibliothek der Freien Universität Berlin)” This study demonstrated that combining amorphization and nanonization of drugs enhances both saturation solubility and dissolution rate, potentially offering therapeutic benefits for formulations like dermal applications.
This study reports that hair samples can be used to track chronic hormone levels, revealing stress, reproductive, and sodium regulation patterns in wildebeest related to environmental factors.
7 citations
,
February 2021 in “Legal Medicine” This study reports two cases of fatal metformin intoxication with hair concentrations significantly higher than those in subjects under treatment, marking the first use of hair analysis for such cases.
January 2023 in “Journal of orthopedics & bone disorders” This study suggests that platelet-rich plasma's high levels of growth factors may be limited in promoting bone regeneration due to the concurrent release of Dickkopf-1, which inhibits osteogenesis.
81 citations
,
September 2005 in “The American journal of pathology” This study found that activin affects both stromal cells and keratinocytes in skin morphogenesis and repair, with dose-dependent effects on keratinocytes demonstrated through transgenic mouse models.
2 citations
,
October 2010 in “European Journal of Drug Metabolism and Pharmacokinetics” Researchers developed a quick and sensitive way to measure finasteride in blood using a small sample size.
9 citations
,
April 2018 in “Journal of trace elements in medicine and biology” This review presents the practice of using hair bioelement analysis to assess nutritional status or environmental exposure, proposing complex interactions and hypotheses regarding depression and autism but reports no new clinical results.
25 citations
,
May 2020 in “EMBO reports” This review discusses the potential roles of calcium in the regulation of pluripotent and tissue-specific stem cells but reports no new experimental results, highlighting areas for future research.
May 2024 in “Journal of colloid and interface science” This study developed a bilayer bionic skin scaffold that mimics the skin's structure to resist microbial invasion and enhance wound healing, with in vivo animal studies showing improved collagen deposition, neovascularization, and hair follicle formation.
July 2026 in “Journal of Investigative Dermatology” Tissue stiffness affects sweat gland development by guiding cell differentiation through specific signals.
April 2023 in “Advanced functional materials” This study created a Wnt3a protein gradient using Multiphoton Microfabrication technology, which improved hair-inductive properties in mouse and human hair dermal papilla cells, suggesting potential applications in hair regeneration research and drug screening.
140 citations
,
April 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that mice lacking the 1αOHase enzyme, which is responsible for producing a key vitamin D metabolite, showed impaired epidermal differentiation and delayed recovery of skin barrier function after disruption.
25 citations
,
September 2006 in “Birth Defects Research” This article discusses various skin pattern formations, their molecular mechanisms, and highlights the need for further understanding to connect molecular biology with organism phenotypes, without providing new clinical findings.
15 citations
,
June 2019 in “eLife” This study identified Activin A and follistatin as key regulators of hair cell differentiation in the mammalian auditory sensory epithelium, with Activin A signaling influencing the timing and pattern of cell differentiation.
13 citations
,
September 2020 in “Sensors” This study used melamine formaldehyde particles to measure a pH gradient along the hair shaft, showing a significant pH decrease from the hair sheath to the external shaft.
10 citations
,
June 1998 in “International Journal of Dermatology” This article discusses inflammatory perifollicular fibrosis and alopecia but provides no new research findings.