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This study found that Adapalene, Diosmin, and Azelastine have potential as multi-target drugs against Onchocerca volvulus and its endosymbiont, which might offer new therapeutic options for treating river blindness, but further research is needed to confirm their effectiveness.

This study used molecular docking simulations to identify Adapalene, Diosmin, and Azelastine as promising drugs for repurposing against Onchocerciasis by targeting Onchocerca volvulus and its endosymbiont; further research is suggested to confirm their efficacy.

This study used molecular docking simulations to identify Adapalene, Diosmin, and Azelastine as promising drugs for repurposing against onchocerciasis by targeting proteins in the parasite and its endosymbiont; further research is needed to confirm their efficacy.

This study found that Ishophloroglucin A from brown seaweed may treat androgenic alopecia by inhibiting 5α-reductase and promoting hair growth-related factors in human dermal papilla cells.

This study found that a topical emulsion containing purified extracts of sidr leaves and roasted candlenut seeds significantly increased hair growth compared to the base and 2% minoxidil, potentially through their antioxidant and anti-inflammatory properties.

This study found that supercritical fluid extraction of germinated perilla seed significantly promoted hair follicle cell proliferation and gene expression related to hair growth, suggesting its potential as a natural treatment for hair loss.

In this study, a film-forming spray with rosemary essential oil increased hair density in volunteers over 16 weeks, suggesting it has potential efficacy for treating androgenetic alopecia by enhancing hair density restoration.

This review discusses recent advancements in the development and use of polymer-based nanohydrogels for topical drug delivery, noting their potential to enhance drug loading, release control, and skin penetration for treating dermatological conditions.

This study found that compound 4 from Urtica triangularis subsp. pinnatifida exhibited stronger anti-BPH activity against BPH-1 cells with an IC50 of 79.75 μM compared to finasteride's IC50 of 91.8 μM, while compounds 1, 2, and 5 showed moderate activity.

This study used LC-HRMS to detect undeclared pharmaceutical ingredients like minoxidil and finasteride in hair serums, finding risk to public health due to their toxicological properties and advocating for manufacturer transparency.

This review discusses hormonal treatment strategies for both binary and non-binary transgender people, highlighting the need for personalized approaches and the importance of future research on long-term outcomes.

This review discusses the potential of phytochemicals from plants as alternative treatments for prostate cancer, highlighting their possible benefits over current 5-alpha-Reductase inhibitors, but reports no new findings.

This study used machine learning to develop classifiers for identifying effective inhibitors of 5α-reductase isozyme 2, achieving high performance in distinguishing potent from weak inhibitors.

Cataract surgery in Europe varies in frequency and cost between countries.

This presentation by Dr. Shutsung Liao suggests that a treatment approach involving cyclic use of androgens and anti-androgens, along with green tea extract, may help extend survival in advanced prostate cancer patients resistant to standard therapy.

In this review, the authors found that cannabinoids and steroid-related drugs show potential for treating Tourette syndrome, but existing evidence is limited and further research is needed to confirm their efficacy and safety.

This study reviewed eight studies investigating transcutaneous drug delivery via fractional laser and microneedling for alopecia treatment, with six studies showing improved hair regrowth over topical therapy alone, suggesting its potential as a promising treatment strategy, although further research is needed to refine treatment parameters.

This study notes the ongoing challenge in developing new drugs for androgenetic alopecia, mentioning that both minoxidil and finasteride were originally intended for treating hypertension. Results are not reported.

This study identified novel 4-Amino-2H-benzo[h]chromen-2-one analogs as potent androgen receptor antagonists that show strong antiproliferative activity against prostate cancer cells, suggesting them as potential lead compounds for therapy development.

This study observed that a combination of sinapic acid and glabridin from Zhimo herbal extract improved hair growth and reduced oxidative stress in a DHT-induced model of androgenetic alopecia in mice by preventing ferroptosis and stabilizing β-Catenin, offering potential application for AGA treatment.

In this study, quercetin and kaempferol, two plant-derived flavonoids, showed stronger binding affinities to JAK3 kinase and moderate binding to 5-alpha reductase type 2, suggesting their potential as natural treatments for androgenetic alopecia, with quercetin demonstrating suitable properties for topical application.

This study used molecular docking to analyze the binding affinities of quercetin and kaempferol, plant-derived flavonoids, showing they have promising interaction profiles with JAK3 kinase and moderate binding with 5-alpha reductase type 2, suggesting potential as topical treatments for androgenetic alopecia.

In this study, XZYFD, a Traditional Chinese Medicine formulation, was found to improve androgenetic alopecia in a testosterone-induced mouse model by promoting hair regrowth, restoring follicular morphology, and modulating androgen metabolism, MAPK signaling, and lipid metabolism pathways, suggesting potential benefits for patients with metabolic dysfunction.

This review explores plant-derived phytochemicals, such as phytosterols, polyphenols, and fatty acids, for their potential use as alternative treatments for prostate cancer, emphasizing their effects on 5-alpha-Reductase enzyme isozymes. It reports no new clinical results.

This study explored a novel finasteride-loaded nanoparticle gel for treating alopecia areata, finding that it significantly increased hair follicle number and size without causing skin irritation, presenting an effective alternative to traditional minoxidil treatments.

Finasteride effectively inhibits 5α reductase, while plant extracts like Permixon and Bazoton don't show significant results.

This study found that the desolvation of finasteride hydrate solvates is highly dependent on the physical environment, complicating investigations but providing insight through complementary analysis techniques.

Validated method reliably measures finasteride in tablets using liquid chromatography.

In this study, patients informed about finasteride's potential sexual side effects reported a significantly higher occurrence of these side effects, suggesting a nocebo effect.

This study found that oral administration of finasteride to pregnant rats caused dosage-related developmental toxicities, including hypospadias and decreased anogenital distance in male offspring.