Novel Potential Avenues for the Therapy of Tourette Syndrome: Cannabinoid- and Steroid-Based Interventions

    January 2022 in “ International review of movement disorders ”
    Marco Bortolato, Roberto Cadeddu
    Studysummary In this review, the authors found that cannabinoids and steroid-related drugs show potential for treating Tourette syndrome, but existing evidence is limited and further research is needed to confirm their efficacy and safety.
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    Research cited in this study 12

    1. Allopregnanolone Is Required for Prepulse Inhibition Deficits Induced by D1 Dopamine Receptor Activation Psychoneuroendocrinology · 2019
    2. Isoallopregnanolone Reduces Tic-Like Behaviors in the D1CT-7 Mouse Model of Tourette Syndrome Journal of Neuroendocrinology · 2019
    3. Allopregnanolone Mediates the Exacerbation of Tourette-Like Responses by Acute Stress in Mouse Models Scientific reports · 2017
    4. The Neurosteroidogenic Enzyme 5α-Reductase Modulates the Role of D1 Dopamine Receptors in Rat Sensorimotor Gating Psychoneuroendocrinology · 2015
    5. Adverse Effects of 5α-Reductase Inhibitors: What Do We Know, Don't Know, and Need to Know? Reviews in Endocrine and Metabolic Disorders · 2015
    6. The Implication of Neuroactive Steroids in Tourette's Syndrome Pathogenesis: A Role for 5α-Reductase? Journal of neuroendocrinology · 2013
    7. Inhibition Of 5α-Reductase Attenuates Behavioral Effects Of D1-, But Not D2-Like Receptor Agonists In C57BL/6 Mice Psychoneuroendocrinology · 2012
    8. A Preliminary Study of Finasteride in Tourette Syndrome Movement Disorders · 2011
    9. Steroid 5α-Reductase as a Novel Therapeutic Target for Schizophrenia and Other Neuropsychiatric Disorders Current Pharmaceutical Design · 2011
    10. Antipsychotic-Like Properties of 5-Alpha-Reductase Inhibitors Neuropsychopharmacology · 2008
    11. Treatment of Tourette’s Syndrome With Finasteride American Journal of Psychiatry · 2007
    12. Finasteride Induced Depression: A Prospective Study BMC clinical pharmacology · 2006

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    1. Novel Potential Avenues for the Therapy of Tourette Syndrome: Cannabinoid- and Steroid-Based Interventions International review of movement disorders · 2022