Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

The study found that growing dermal papilla cells in 3D spheroids enhances their activity with hair growth-promoting agents, such as minoxidil and TCQA, compared to traditional 2D cultures.

This study observed that the compound EM-402 reduced 5α-reductase activity and sebaceous gland size in the flank organs and ears of hamsters, indicating potent localized anti-androgenic effects without systemic action.

This study found that caffeic acid amide derivative, compound 4, effectively inhibited steroid 5α-reductase type 1 in vitro, suggesting potential for development as a treatment for androgenic alopecia.

This literature review on neurocosmetics found that both nature-derived peptides and synthetic molecules can improve skin concerns like aging and pigmentation, while also promoting emotional well-being; however, gaps in long-term efficacy and personalized approaches remain.

This review discusses the potential uses of 5α-reductase inhibitors for conditions ranging from benign prostatic hyperplasia to skin disorders like acne and male pattern baldness, but it reports no new clinical results.

This study identified novel compounds as selective inhibitors of the type 1 isoenzyme of 5α-reductase, displaying promising potential for treating DHT-dependent disorders such as acne and androgenic alopecia.

This study found that treatment with the polyphenolic compound TCQA activated β-catenin, promoting hair regrowth and the initiation of the anagen phase in mice and human dermal papilla cells.

In this study, 33% of mice treated with polyphenol extract from green tea showed significant hair regrowth, while no control group mice exhibited hair growth.

This study found that ethanolic extracts of Buebang 3 CMU may promote hair growth and prevent hair loss more effectively than minoxidil by enhancing bioactive compounds and activating key signaling pathways.

In this study, the synthesis and testing of new pyrroloquinoline derivatives identified compound 7p, which showed low micromolar cytotoxic activity against MCF-7 and HeLa cells, highlighting its potential for development into a potent anticancer agent.

This study found that pregnane derivatives with higher lipophilicity, like compound 9d, had stronger androgen receptor binding and greater antiandrogenic effects in rats, correlating relative binding affinity with log P values.

This study identified several compounds from traditional Chinese medicines that may inhibit prostaglandin D2 synthase, potentially providing promising candidates for treating androgenic alopecia with minimal adverse skin reactions.

This study reported that compounds isolated from Alpinia zerumbet significantly promoted hair cell growth and exhibited anticancer activity in cell cultures, suggesting potential as treatments for alopecia and cancer.

This case report presents the first Russian patient with Meier-Gorlin syndrome 5, expanding clinical understanding through the identification of two novel CDC6 gene variants.

This narrative review highlights the potential of naturally occurring compounds to target specific molecular pathways and overcome resistance in advanced and recurrent papillary thyroid cancer, offering new therapeutic possibilities beyond traditional treatments like surgery and lifelong hormone replacement.

This study found that compounds from Ziziphus spina-christi roots exhibited promising antibacterial and antioxidant activities, supporting its traditional medicinal use.

This synthesis report details the successful development of a C-14 labeled isotopomer of LY300502, a 5α-reductase inhibitor, through a multi-step radiochemical process.

In this study, araliadiol, a plant-derived compound, exhibited senomorphic effects in three dermal fibroblast senescence models, suggesting its potential as a topical treatment to mitigate skin aging by reducing certain senescence-related markers and increasing procollagen type I content.

This study found that escin acts as a natural agonist of the Wnt/β-catenin signaling pathway in cultured human dermal papilla cells by promoting the degradation of GSK-3β, highlighting its potential therapeutic use for conditions like androgenetic alopecia and vitiligo.

This study developed a new competitive 5alpha-reductase inhibitor with an IC(50) of 0.84 microM using a novel chemical structure.

This study found that trans-3,4'-Dimethyl-3-hydroxyflavanone reduces active TGF-beta2 levels in human keratinocytes, suggesting it may enhance hair growth by suppressing the TGF-beta2 activation pathway.

This study identified novel 4-Amino-2H-benzo[h]chromen-2-one analogs as potent androgen receptor antagonists that show strong antiproliferative activity against prostate cancer cells, suggesting them as potential lead compounds for therapy development.

In this study, TASP0382088 showed potent selective inhibition of the ALK5 receptor, significantly reducing Smad2 phosphorylation in mouse skin following topical application.

This study investigated pyranoanthocyanin Vitisin A and found it significantly lowered triglyceride levels and reduced body weight in high-fat diet-fed mice, outperforming Cyanidin-3-O-glucoside by inhibiting hepatic lipogenesis and enhancing fatty acid β-oxidation.

This study found that 2MbisP increases epidermal thickening more rapidly than atRA in rhino mice, while both compounds similarly reduce utricle size.

This study reported that newly synthesized phenanthridin-3-one derivatives effectively inhibit human steroid 5-α-reductase.

This study reports the crystal structure and geometric parameters of a modified Finasteride derivative, highlighting significant differences in dihedral angles compared to its solvated analog and computational models.

This study found that Punica granatum ethanolic leaf extract may alleviate skin fibrosis in rats by modulating inflammation-related pathways and reducing dermal alterations.

This study reports that intramuscular compound betamethasone may offer rapid, short-term reduction in hair shedding for patients with telogen effluvium, particularly within a week, but often requires repeated treatments; only mild side effects were observed.

This study concluded that TrichoxidilTM positively affected hair growth by increasing growth factor expression and fibroblast proliferation, suggesting it may be a promising treatment for androgenetic alopecia.