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This study develops FR-1, a topical small molecule, which reduces scarring and avoids skin atrophy in a murine wound model, showing potential for treating fibrosis without the side effects of current therapies.

In this study, transcutaneously applied nanoparticles and viral vectors were shown to penetrate murine hair follicles, internalize in antigen-presenting cells, and induce immune responses, suggesting a promising approach for vaccine delivery.

This study identified novel mutations in the DSG4 gene in a Japanese patient with monilethrix, affecting protein interactions that may disrupt hair shaft structure.

In this study, Gaussian process regression models combined with Grey Wolf optimization were used to predict and optimize phenolic and flavonoid content extraction from Carthamus caeruleus L. rhizomes, showing high accuracy and helping improve understanding and extraction processes through a new interactive tool.

This study found that Ganoderma lucidum extracts showed weak 5alpha-reductase inhibition but significantly inhibited prostate cell proliferation and testosterone-driven prostate growth in rats, suggesting potential as an ingredient for treating androgen-induced diseases.

This study found that Centipeda minima extract promotes hair growth by activating Wnt/β-catenin, ERK, and JNK signaling pathways in human hair follicle dermal papilla cells.

This study observed that the compound EM-402 reduced 5α-reductase activity and sebaceous gland size in the flank organs and ears of hamsters, indicating potent localized anti-androgenic effects without systemic action.

This study found that extracts from Indian gooseberry leaves showed strong antimalarial activity against Plasmodium falciparum, with low cytotoxicity, suggesting potential for developing new antimalarial drugs.

This review summarizes the mechanisms by which Plumbagin, a naphthoquinone derived from plants, may impact inflammation and explores its potential biological effects, highlighting areas that require further comprehensive research before considering it for therapeutic use.

This study developed a multifunctional dressing with the MeGel-SFSR composition, which showed faster healing and better tissue regeneration in diabetic wounds compared to controls, by utilizing a herbal compound and enhanced mechanical support, promoting hair follicle regeneration, collagen deposition, reduced inflammation, and vascularization in vivo.

This study used a multi-layer in silico framework to evaluate Korean herbal compounds for androgenetic alopecia, identifying Biochanin A, Saponin Re, and Emodin as potential topical candidates with distinct safety and affinity profiles, although these findings remain purely computational without experimental validation.

This study conducted an in silico evaluation of Korean herbal compounds against key targets involved in androgenetic alopecia, finding Biochanin A, Saponin Re, and Emodin as promising candidates for topical treatments, but highlighting safety and topical formulation challenges.

This study identified Saponin Re and Emodin as top candidates for treating androgenetic alopecia, suggesting future research in dermal papilla cell cultures and scalp organoids despite safety concerns.

This study reported discovering a novel missense variant in a case of autosomal recessive woolly hair in a 31-year-old Chinese woman, which significantly reduced secretion of the encoded protein, likely leading to disease by impairing its hydrolytic function.

This study reports that different Armillaria species significantly affected both the yield and active compound content of Polyporus umbellatus sclerotia, with A541 achieving the highest results.

This study presents a new automated method for measuring total phenolic compounds in Ziziphus Jujuba fruit extract, showing high precision and potential applications in health and environmental sciences.

This review examines the potential role of odorant receptors in human skin cells responding to flavor compounds and their implications for skin health and disease, without providing new clinical results.

In this study, researchers evaluated the antifungal effectiveness of topical products on infected kitten hair, finding most were effective after one application, with enilconazole and lime sulfur showing residual activity; however, 0.15% ketoconazole with chlorhexidine had no such lasting effect.

This study found that camphor and similar compounds depress neural activity in rat mechanoreceptors, suggesting that their effects may not be mediated through TRP channels.

This study investigates the potential of onion extract as a treatment for androgenetic alopecia by using in silico and ADME/T analyses to examine how active compounds from onions interact with the 5-alpha-reductase enzyme.

3D spheroid cells effectively test hair growth compounds like Minoxidil.

This research outlines a chemical synthesis process for Finasteride, detailing the conversion of pregnadienolone acetate through various chemical reactions and modifications.

This study found that Prosopis farcta is a rich source of phenolic compounds with strong antioxidant activity, suggesting its potential for use in food, beverage, feed, and pharmaceutical applications.

This study examined the stability of two 5α-reductase inhibitors in Tectona grandis extracts, finding that they are more stable in acidic environments and degrade rapidly under heat and light unless protected, suggesting the need for careful storage when developing anti-hair loss medications.

This review explores how colloidal drug delivery systems can enhance the stability, absorption, and bioavailability of phytochemicals, potentially rediscovering ancient compounds' therapeutic benefits and overcoming limitations like poor solubility and bioavailability.

This review discusses the potential of plant polyphenols to overcome multidrug resistance in various solid cancers and reports no new experimental results; further research is suggested.

This study extended a skin diffusion model to include a porous pathway, effectively explaining the permeability of both polar and lipophilic solutes through the stratum corneum.

This study found that Scutellaria baicalensis extract and its main component baicalin inhibited androgen activation signaling and promoted proliferation of human dermal papilla cells, suggesting potential use in treating androgen-associated disorders.

This review discusses the phytochemistry and pharmacological activities of Perilla frutescens, detailing its bioactive compounds and their potential health benefits, but reports no new clinical results.

This review assessed experimental studies on herbs used for alopecia, identifying potential mechanisms involving hair cycle management and keratinocyte processes, but highlighted a need for improved evidence on quality control and toxicity of these herbal treatments.