Unscrewing DHT-Blocking Properties of Allium Cepa Extract: Virtual Screening of Active Compounds Against 5-Alpha Reductase and Evaluation of ADME/T Properties of Compounds

    July 2023 in “ Zenodo (CERN European Organization for Nuclear Research) ”
    Kashif Abbas, Tanjeem Raza, Akbar Hussain, Mudassir Alam
    TLDR Onion extract may help treat hair loss by blocking a key enzyme.
    The study investigates the potential of Allium cepa (onion) extract as a natural treatment for androgenetic alopecia (AGA) by targeting the enzyme 5-alpha-reductase, which is responsible for converting testosterone into dihydrotestosterone (DHT), a key factor in hair loss. Through virtual screening and ADME/T analyses, the research evaluates the interaction of active compounds in onion extract with the 5-alpha-reductase protein. The findings suggest that these compounds may inhibit the enzyme, offering a promising natural approach to managing AGA.
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