Enzyme Inhibitory Activity of Certain Vegetables Indigenous in Iran as Potential Antiandrogens

    Anousheh Sharifan, Ashraf Hajhoseini, Mahdi Bakhtiari
    TLDR Garlic and fenugreek may help treat hair loss.
    The study investigated the 5α-reductase inhibitory activity of ethanol-based extracts from Olea europaea, Trigonella foenum-graecum, and Allium sativum, which are traditionally used in Iran for culinary and medicinal purposes. The research aimed to explore their potential as antiandrogens for managing androgenetic alopecia, a common type of hair loss. The study involved six samples, including enzyme and control groups. The results showed that Allium sativum and Trigonella foenum-graecum exhibited strong enzyme inhibitory activities, suggesting that these herbal extracts could be developed into new treatments for testosterone-induced conditions like androgenic alopecia.
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