8 citations
,
May 2025 in “Acta Obstetricia Et Gynecologica Scandinavica” This meta-analysis reported that dienogest and combined oral contraceptives had comparable efficacy and tolerability for endometriosis treatment, with therapeutic choice suggested to be based on patient preference and clinical history.
November 2023 in “Systems Biology in Reproductive Medicine” This study assessed vitamin E and a combined oral contraceptive's impact on continuous light-induced PCOS in female rats, finding they reduced testosterone levels and modified oxidative stress, suggesting benefits via melatonin-related pathways.
3 citations
,
July 2022 in “BJOG: An International Journal of Obstetrics and Gynaecology” This study reports that among young women, combined oral contraceptives containing chlormadinone, among others, are associated with an increased risk of venous thromboembolism compared to those containing levonorgestrel with low ethinylestradiol.
October 2025 in “Pielegniarstwo XXI wieku / Nursing in the 21st Century” This review discusses the effectiveness and mechanisms of combined oral contraceptives in treating acne vulgaris but reports no new clinical results; the authors highlight their antiandrogenic effects for managing acne and related endocrine disorders.
46 citations
,
January 2007 in “The European Journal of Contraception & Reproductive Health Care” This review discusses the increased risk of venous thromboembolism associated with combined hormonal contraceptives, particularly noting higher risks with certain progestins like desogestrel, gestodene, and cyproterone acetate, but reports no new clinical findings.
August 2010 in “Springer eBooks” Hormonal contraceptives are effective for teens but require careful consideration of side effects and individual health.
22 citations
,
January 2013 in “Journal of The American Academy of Dermatology” This review discusses the role of contraceptives in dermatology, particularly for acne treatment and managing patients on teratogens, but reports no new clinical results.
21 citations
,
July 2014 in “Clinics in Dermatology” This review examines the role of hormones in acne pathogenesis, the use of hormonal therapies for treatment, and the importance of contraceptive counseling during isotretinoin therapy, but reports no new clinical results.
December 1982 in “PubMed” This review discusses the use of different types of oral contraceptive pills and highlights their effectiveness, potential side effects, and contraindications without presenting new clinical data.
March 2007 in “Journal of Obstetrics and Gynaecology Canada” This review discusses the diagnosis and treatment of hyperandrogenism in women, emphasizing that cyproterone acetate is effective for severe hirsutism, though it reports no new clinical findings.
8 citations
,
April 2022 in “Revista Brasileira Ginecologia e Obstetrícia” This review explores contraceptive options for women with polycystic ovary syndrome, emphasizing the need for tailored choices based on individual clinical, hormonal, and metabolic profiles, but reports no new clinical findings.
This article reviews the effects of combined oral contraceptives on skin conditions and suggests prescribing guidelines for women with acne, as it reports no new clinical results.
This review discusses contraceptive options for adolescent girls, highlighting potential recommendations and contraindications, and reports no new clinical findings.
42 citations
,
May 2009 in “Contraception” This study found that the combined oral contraceptive containing ethinyl estradiol and chlormadinone acetate was effective in reducing moderate papulopustular acne and other androgen-related skin disorders compared to placebo.
30 citations
,
April 1997 in “European journal of endocrinology” The document concludes that managing hirsutism involves identifying the cause, using a scoring system for severity, combining cosmetic and medical treatments, encouraging weight loss, and providing psychological support, while noting the need for more research on drug treatments.
19 citations
,
January 2013 in “Pediatrics in review” This review discusses the onset of menstruation and related challenges in young women, with a focus on primary amenorrhea, its diagnosis, and management strategies, and reports no new clinical findings.
12 citations
,
October 2004 in “Expert Opinion on Investigational Drugs” This review discusses current and emerging therapeutic strategies for managing polycystic ovary syndrome, emphasizing treatment tailored to individual patient complaints and highlighting the roles of hormone therapy and insulin-sensitizing agents.
9 citations
,
August 2024 in “Australian Prescriber” This review highlights that pharmacotherapy for polycystic ovary syndrome should address individual patient concerns, with metformin beneficial for reducing weight and metabolic risk, and lifestyle modifications also important.
9 citations
,
March 2022 in “Journal of the Endocrine Society” This study found that testosterone more accurately predicts PCOS diagnosis than 11-oxyandrogens, which were linked with hirsutism severity and showed varying responses to contraceptive and metformin treatments.
7 citations
,
August 2023 in “EClinicalMedicine” This study reported that anti-androgens combined with lifestyle modifications were more effective than metformin and lifestyle in reducing hirsutism and certain hormonal measures in women with PCOS, but they were not more effective than a placebo combined with lifestyle changes.
6 citations
,
August 2023 in “Fertility and Sterility” This review details the 2023 International Guideline update for assessing and managing polycystic ovary syndrome, which provides evidence-based recommendations to improve care and patient outcomes but notes the remaining low to moderate quality of evidence.
5 citations
,
January 2024 in “Journal of the American Academy of Dermatology” This study provided 18 evidence-based recommendations for managing acne vulgaris, strongly endorsing treatments like benzoyl peroxide, topical retinoids, and oral isotretinoin for severe cases, and issued conditional recommendations for therapies like salicylic acid and spironolactone, while offering good practice statements on combining treatment methods.
4 citations
,
November 2023 in “Acta obstetricia et gynecologica Scandinavica” In this guideline update, researchers emphasized refining diagnostic criteria for polycystic ovary syndrome using ultrasound or hormone levels, while highlighting a healthy lifestyle's importance without specific diet recommendations, and reviewed treatments with a focus on comorbidities and pregnancies from a Nordic standpoint.
3 citations
,
December 2024 in “EClinicalMedicine” Anti-androgens are not better than birth control pills for PCOS, but can help with excess hair if pills don't work.
2 citations
,
July 2012 in “Obstetrics, gynaecology and reproductive medicine” This article reviews the physiology, causes, and treatments of hirsutism and reports no new research findings.
1 citations
,
July 2006 in “Reviews in gynaecological and perinatal practice” This review explores various therapeutic options for managing female hirsutism, emphasizing the effectiveness of low-dose finasteride and cyproterone acetate, but it presents no new clinical results.
1 citations
,
August 2013 in “Springer eBooks” Birth control pills and anti-androgen medications help manage hair growth, acne, and hair loss in women with PCOS.
May 2021 in “Journal of the Endocrine Society” This study found that while 11-oxyandrogens do not aid in diagnosing PCOS, they correlate with hirsutism severity, and 11-ketotestosterone levels decrease with combined oral contraceptive therapy.
June 2015 in “Obstetrics, gynaecology and reproductive medicine” This article reviews the causes, physiology, and treatment strategies for hirsutism in women, highlighting that effective management often requires addressing underlying conditions and may involve lifestyle changes and pharmacological interventions.
This study found that while 11-oxyandrogens are linked to excess hair growth, they do not aid in diagnosing PCOS and require further research to determine their clinical utility.