44 citations
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June 1985 in “Fertility and sterility” This study suggests that combination drug therapy with spironolactone and either oral contraceptives or dexamethasone effectively manages unresponsive hirsutism, with eight of nine patients achieving satisfactory clinical responses.
June 2026 in “Journal of Cosmetic Dermatology” This review highlights that combination pharmacotherapy for androgenetic alopecia may offer enhanced hair growth efficacy and reduced side effects through distinct mechanisms, allowing for personalized treatment regimens that improve patient compliance and therapeutic outcomes.
This study developed a bioresponsive hydrogel combining basic fibroblast growth factor and N-acetylcysteine, which significantly improved diabetic wound healing by enhancing re-epithelialization, collagen deposition, hair follicle regeneration, and neovascularization in response to oxidative stress.
1 citations
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January 2014 in “Hair therapy & transplantation” This case study reports the first extensively interpreted instance of dystrophic telogen effluvium potentially linked to pegylated interferon and ribavirin therapy for chronic hepatitis C, characterized through clinical and trichogram analysis.
1 citations
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November 2023 in “BMC chemistry” In this study, researchers used computational modeling and virtual screening to identify two FDA-approved drugs, Tadalafil and Finasteride, that may effectively inhibit key proteins involved in melanoma progression, suggesting potential for new therapeutic strategies against aggressive melanoma.
In this study, the researchers identified that perturbing both AKT1 and MDM2 significantly reduces epithelial-mesenchymal transition in melanoma, proposing Cialis and Finasteride as potential therapeutic candidates with favorable properties for managing aggressive melanoma.
January 2004 in “Zhongguo yiyuan yongyao pingjia yu fenxi” This study found that combining tamsulosin with finasteride was the most cost-effective treatment for mild to moderate BPH among the regimens tested.
November 2021 in “International journal of life science and pharma research” This study reported that a solid lipid nanoparticle-based gel formulation, specifically optimized for psoriasis, improved drug loading capacity and release properties using high-pressure homogenization, suggesting its potential efficacy as a topical treatment.
September 2020 in “Zenodo (CERN European Organization for Nuclear Research)” In this study, researchers identified indometacin as a suitable active ingredient for a combination gel aimed at treating mastopathy and preventing breast cancer, establishing its concentration using literary analysis, marketing research, and in vitro biopharmaceutical methods.
February 2024 in “Journal of Cosmetic Dermatology” This clinical trial found that combining fractional CO2 laser with bimatoprost solution significantly improved alopecia areata treatment outcomes compared to bimatoprost alone, as measured by a more substantial reduction in SALT scores and higher patient satisfaction over 12 weeks.
November 2003 in “Aap Grand Rounds” This study found that a combination of low-dose flutamide and metformin therapy may reverse insulin resistance and reduce fat mass in nonobese adolescents with PCOS.
1 citations
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September 2022 This case report describes a patient who developed drug-induced lupus erythematosus after treatment with a monoclonal antibody combination against the SARS-CoV-2 surface protein, highlighting the need for careful follow-up.
21 citations
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January 1998 in “Urologia internationalis” This study found that combining dibenyline and finasteride for symptomatic BPH treatment offered modest improvements with fewer additional side effects compared to each drug alone.
January 2020 in “International Journal of PharmTech Research” This case report describes a patient with untreated lepromatous leprosy developing Lucio's phenomenon, highlighting difficulties in distinguishing it from erythema nodosum leprosum with vasculonecrotic lesions.
August 2026 in “Journal of Dermatologic Science and Cosmetic Technology” In this review, researchers critically examine contemporary treatments for androgenetic alopecia, emphasizing advanced drug delivery systems, regenerative medicine, and emerging molecular targets, while identifying significant gaps that hinder translating these innovations into clinical practice.
June 2026 in “Facial Plastic Surgery” This review concluded that non-surgical hair restoration methods, such as pharmacologic and regenerative therapies, are important for delaying or supplementing surgical treatments when used properly.
39 citations
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August 2022 in “Pharmaceutics” This study found that the combination of letrozole and quercetin loaded in spanlastics showed enhanced cytotoxicity and other anticancer effects against MCF-7 breast cancer cells compared to individual treatments.
November 2025 in “Вопросы современной педиатрии” In this case report, the researchers observed that combining growth hormone therapy with the biologic drug dupilumab effectively improved growth and health outcomes in a patient with Netherton syndrome and comorbid hypopituitarism, suggesting a multidisciplinary approach may be beneficial for managing such cases.
June 1996 in “Archives of Dermatology” This article reviews a case of impressive hair regrowth in a man with androgenetic alopecia using a combination of topical minoxidil and tretinoin, but provides no clinical trial results; the authors call for informed consent before recommending this treatment.
1 citations
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January 2025 in “BIO Integration” This review highlights that the combination of ultrasound and microneedles can enhance transdermal drug delivery by using physical and energy-driven mechanisms to improve drug penetration into deeper skin layers, with implications for precision medicine and chronic disease treatments.
36 citations
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June 1990 in “Archives of Dermatology” This study found that combination therapy with 5% minoxidil and 0.5% anthralin led to hair regrowth in some patients with severe treatment-resistant alopecia areata, but also caused mild to moderate irritant dermatitis in all participants.
1707 citations
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December 2003 in “The New England Journal of Medicine” Combination therapy of doxazosin and finasteride safely and effectively reduces benign prostatic hyperplasia progression risk.
32 citations
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January 2010 in “Dermatology” This review discusses the combination of laser hair removal and topical eflornithine for managing resistant hirsutism, providing guidance based on existing clinical data, but reports no new results.
1 citations
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January 2024 in “Journal of the American Pharmacists Association” In this study of transgender and gender-diverse adults, the researchers observed that one-third of those on psychotropic medications within two years of starting hormone therapy experienced psychotropic polypharmacy, with a significantly higher likelihood of potential drug-hormone interactions in this group.
1 citations
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April 2009 in “Expert Review of Dermatology” This study found that the once-daily gel combining calcipotriene and betamethasone dipropionate was more effective and faster in treating scalp psoriasis compared to individual treatments, with a similar safety profile.
February 2026 in “International Journal of Clinical Dermatology” In this study, an 8-year-old girl with dermatomyositis and extensive calcinosis showed complete clearance of calcinosis and good disease control after treatment with a combination of corticosteroids, methotrexate, hydroxychloroquine, pamidronate, and intravenous immunoglobulin.
January 2006 in “Zhongguo yaofang” This study concluded that qianliekang combined with liuweidihuangwan is a more economical treatment for benign prostatic hyperplasia compared to finasteride plus tamsulosin.
13 citations
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August 2013 in “Journal of pharmaceutical sciences” This study found that a transdermal delivery system using 3% azone and P407 gel may enhance the skin permeation of doxazosin and finasteride for treating benign prostatic hyperplasia.
8 citations
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January 1977 in “Acta Haematologica” This study found that the PVP protocol, combining Peptichemio, vincristine, and 6-methylprednisolone, resulted in remission for diffuse non-Hodgkin's lymphomas with moderate side effects.
1 citations
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October 2010 in “Faṣlnāmah-i bīmārīhā-yi pūst” This study found that using methotrexate with corticosteroids may support hair regrowth in severe alopecia areata, but adverse effects and relapses were common, suggesting more controlled trials are needed.