Drug Therapy in Polycystic Ovarian Syndrome

    November 2003 in “ Aap Grand Rounds ”
    Susan R. Rose
    Image of study
    TLDR Low-dose flutamide-metformin therapy effectively improved PCOS symptoms in adolescent girls.
    The document discusses a study conducted on thirty adolescent girls aged between 13.6 and 18.6 years with polycystic ovary syndrome (PCOS) or hyperinsulinemic ovarian hyperandrogenism. The study, which took place in Barcelona, Spain, evaluated the effects of a 1-year treatment with low-dose flutamide (125mg/day) and metformin (1,275mg/day). The participants were monitored for body composition, hormonal levels, insulin sensitivity, and ovulation. After a 3-month control period with no treatment, the 9-month treatment period resulted in significant improvements: insulin, androgen, and lipid levels decreased, the waist-hip ratio reduced, ovulation rates increased from 7% to 87%, fat mass decreased by 10% (with a 20% decrease in abdominal fat mass), and lean body mass increased with minimal net change in weight. The study concluded that low-dose flutamide-metformin therapy effectively attenuated a wide spectrum of abnormalities associated with PCOS, including excess fat mass and reduced lean mass.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 19 results

      community How does hair loss and recovery work?

      in Chat  12 upvotes 1 year ago
      Hair loss varies due to genetic sensitivity to DHT and other factors. Treatments discussed include finasteride, minoxidil, RU58841, and microneedling.

      community Sugar and Hair loss connections

      in Research/Science  41 upvotes 3 months ago
      High sugar diets may worsen hair loss by increasing 5α-reductase activity and androgen levels, especially in women with PCOS. A low sugar diet might reduce scalp DHT levels, similar to finasteride, but genetics also significantly influence hair loss.

      community C’est terrible - at my wits end

      in Female  450 upvotes 1 year ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

      community PCOS Hair Loss: What’s Helped Me (and What Didn’t)

      in Treatment  10 upvotes 6 days ago
      OP shares their experience with PCOS-related hair loss, highlighting that addressing vitamin D and ferritin deficiencies, managing hormones with spironolactone, and using gentle hair care products helped improve their condition. They advise against relying on "miracle" hair oils and emphasize the importance of medical evaluation and a combined approach to treatment.

    Similar Research

    5 / 1000+ results