Patterns of Psychotropic Medication Prescribing and Potential Drug-Hormone Interactions Among Transgender and Gender-Diverse Adults Within 2 Years of Hormone Therapy

January 2024 in “ Journal of the American Pharmacists Association ”

Alin Miksi Kalayjian, Krisztina D. László, Molly Fassler, Zachary Schonrock, Kikka E. Delarose, Andrew Ly, Clayton English, Lauren R. Cirrincione

hormone therapy drug-hormone interactions psychotropic medication antidepressants sedative-hypnotics psychotropic polypharmacy

TLDR Transgender and gender-diverse adults on hormone therapy often face drug-hormone interactions, especially with multiple psychotropic medications.

This study examined psychotropic medication use and potential drug-hormone interactions among 184 transgender and gender-diverse (TGD) adults within 2 years of starting hormone therapy. It found that 37% of these patients experienced psychotropic polypharmacy, with the most common combinations being antidepressants and sedative-hypnotics. Patients with psychotropic polypharmacy had a significantly higher incidence of potential drug-hormone interactions (33.8%) compared to those without polypharmacy (6.9%). The study highlights the need for increased awareness and management of these interactions to optimize care for TGD individuals. Limitations include potential selection bias and the inability to assess medication adherence or clinical outcomes. Further prospective pharmacokinetic studies are recommended.

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