In a controlled study, researchers observed that lambs exposed to colder temperatures had increased wool growth, thicker skin, altered physiological traits, and activated specific molecular pathways, highlighting potential targets for enhancing cold tolerance, welfare, and productivity in sheep breeds.
26 citations
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February 2020 in “Frontiers in genetics” This study identified three candidate genes (CORT, FGF5, and CD36) associated with cold climate adaptation in Yanbian cattle through genome resequencing and comparison with African tropical cattle.
June 2026 in “Domestic Animal Endocrinology” This study found that hair follicle gene expression varies between Angus and Brahman cattle and responds to growth-promoting treatments, which may reflect breed differences in adaptability to cold stress.
The researchers reported that PPARβ/δ may influence the yak hair follicle cycle by modulating lipid metabolism in dermal papilla cells, with varying expression during different hair growth phases, affecting both lipid content and cell proliferation.
6 citations
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August 2023 in “BMC genomics” This study found that Tibetan cashmere goats have genetic adaptations that contribute to their finer cashmere, possibly enhancing their ability to withstand the cold climate of the Tibetan plateau, while identifying specific genes related to hair growth, pigmentation, and heart development.
January 2026 in “Communications Biology” This study constructed a single-cell atlas of hair follicle cells from yaks and taurine cattle, revealing that differences in WNT signaling within dermal papilla cells may be key to the yak's adaptation to cold environments on the Qinghai-Tibet Plateau.
January 2025 in “Animal Science Journal” This study reported that the coat hairs of golden takin, living in harsh environments, have unique structural features compared to cattle, with overcoat hairs having continuous medullated tissue and undercoat hairs being finely crimped, potentially contributing to temperature regulation in cold conditions.
1 citations
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April 2023 in “Animals” In this study, Min pigs were found to have unique characteristics for secondary hair growth compared to Berkshire and Yorkshire pigs, with the Wnt and BMP signaling pathways stimulating follicle stem cell activity and promoting secondary hair growth and gene expression.
February 2024 in “BMC genomics” This study identified a gene variant in the TRPV3 gene that may explain the suri alpaca phenotype, characterized by longer and less crimped fleece, suggesting this variant's involvement in the development of these hair characteristics compared to the huacaya phenotype.
1 citations
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May 2025 in “Frontiers in Veterinary Science” This study suggests that recombinant Lumpy Skin Disease Virus strains pose a severe threat to yaks in the Qinghai-Tibet Plateau, causing high mortality and emphasizing the need for targeted control strategies.
2 citations
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November 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that metabolic adaptations in skin epithelial stem cells, specifically redox ratio recovery and glycolytic flux modulation, define competitive outcomes between wild-type and mutant cells in different oncogenic environments.
December 2019 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that redhaired individuals consistently had higher calcidiol levels compared to non-redhaired subjects, suggesting a physiological adaptation for vitamin D synthesis in low UV-B conditions.
1 citations
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December 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study investigated pangolin skin genetics, finding that while sweat gland-related genes are not inactivated, several genes related to sebaceous gland function are, which highlights complex evolutionary adaptations in mammalian skin.
April 2017 in “bioRxiv (Cold Spring Harbor Laboratory)” This study introduced the dual-flow-RootChip platform to demonstrate that Arabidopsis roots exhibit non-autonomous adaptations, such as hair growth regulation, when subjected to varied environmental conditions on opposite sides.
2 citations
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October 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This study observed that darker hair is typical in wetter regions for the Indriidae family, while within Propithecus, dark black hair is common in colder forests, suggesting evolutionary adaptations to environmental pressures.
2 citations
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March 2024 in “Supportive Care in Cancer” In this study, manual cold capping was found to be effective in minimizing chemotherapy-induced alopecia, with 92.1% of patients retaining 50% or more of their hair, although effectiveness varied with different chemotherapy regimens.
46 citations
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July 2007 in “Journal of comparative neurology” This study found that Florida manatees have unique types of specialized nerve endings in their vibrissae, which assist in their sensory and manipulative functions in aquatic environments.
June 2026 in “Research Square” This study identified a group of dermal fibroblasts near hair follicle stem cells in mice that facilitate hair regeneration by creating a biomechanically compliant extracellular matrix, enhancing stem cell activation and promoting a positive feedback loop for tissue regeneration.
January 2024 in “Wiadomości Lekarskie” This preclinical study found that exercise-induced extracellular vesicles delayed breast cancer tumor growth in mice, potentially by enhancing the immune response within the tumor microenvironment.
2 citations
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August 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that during wound healing, hair follicle stem cells develop an immune modulatory ability to create a protective immune suppressive niche, facilitating their survival and function amidst inflammation.
March 2026 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, researchers discovered a honeycomb-like structure in the skin of spiny mice that facilitates tissue shedding and regeneration, attributed to a uniquely arranged collagen VI and influenced by spiny hair development.
October 2025 in “bioRxiv (Cold Spring Harbor Laboratory)” This study experimentally validated Lockhart's viscoplastic framework for tip growth in Arabidopsis root hairs by demonstrating alignment with observed growth rates and estimating yield turgor pressure and cell wall viscosity, offering a methodology adaptable to other species and conditions.
May 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that hair-type tissues in hedgehogs show higher enrichment of immune-related genes compared to spine-type tissues, suggesting that spines evolved to protect against injuries and infections.
27 citations
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April 2020 in “Molecular Biology and Evolution” This study found that ancient and modern Chinese goats share close genetic ties, originating from the Fertile Crescent, with genetic divergence influenced by China's climatic divisions.
October 2023 in “Advancement in yoga and physical therapy” This narrative review explores the potential influence of brown adipose tissue on polycystic ovary syndrome and reports no new experimental findings.
88 citations
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August 2014 in “PLOS genetics” This study found that mice lacking syndecan-1 experienced cold stress and metabolic issues due to reduced intradermal fat, which was restored by thermoneutral housing or rosiglitazone treatment.
1 citations
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January 2017 in “Evolutionary studies” This chapter discusses genetic polymorphisms related to phenotypes that differentiate between populations and reports no new results; it highlights the role of DNA technology in understanding human adaptation history.
113 citations
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March 2018 in “Biological reviews/Biological reviews of the Cambridge Philosophical Society” This review examines the adaptive value and mechanisms of seasonal coat colour moulting in birds and mammals, highlighting the challenge of camouflage mismatch and the necessity for evolutionary adaptation under climate change.
65 citations
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September 2014 in “BMC genomics” This research found that variations in the KRTAP gene family are likely responsible for the diverse hair phenotypes seen among mammals, influenced by gene repertoire differences, expression, and evolutionary factors.
9 citations
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November 2024 in “Journal of Wound Management Official journal of the European Wound Management Association” Cold Plasma shows promise for healing wounds by killing bacteria and helping tissue grow.