Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that topical minoxidil 5% foam was effective in promoting hair growth in both the frontal and vertex scalp for men with androgenetic alopecia.

This study identified a regulatory element necessary for Foxn1 expression specifically in mouse thymic epithelial cells, crucial for thymus development but not affecting hair follicles.

This article reviews the genetic research on male androgenetic alopecia, highlighting that over 300 associated risk variants have been identified, with unclear mechanisms of action.

This case report illustrates how SNP array testing helped identify a DCAF17 mutation linked to Woodhouse-Sakati syndrome in consanguineous Qatari siblings with shared features including alopecia and hypogonadotropic hypogonadism.

This study found that lentiginous melanoma had the highest incidence in central facial areas, with men showing higher rates on peripheral head regions and women on central face regions.

This case report discusses a rare instance of pseudolymphomatous folliculitis in a 19-year-old man, highlighting the challenge in diagnosing PLF due to its low clinical suspicion index and variable initial clinical diagnoses.

In this study, sequences upstream of the TGM3 gene were found to regulate epithelial-specific gene expression in keratinocytes, suggesting potential applications in gene therapy.

This review discusses the genetic factors involved in hair follicle morphogenesis and cycling and reports no new clinical results; it emphasizes the role of genes in hereditary hair diseases.

This review discusses the role of microRNAs in skin function and potential therapeutic applications, emphasizing their importance in wound healing and disease management, though it reports no new experimental findings.

This study reports that X chromosomes often show greater differentiation between human populations than autosomes, likely due to a mix of demography and selection pressures.

This study established a mouse model for Cushing's syndrome due to a specific Crh mutation, which may help explore the effects of glucocorticoid excess and evaluate treatments for corticosteroid-induced osteoporosis.

This review examined genetic factors in 46, XY differences/disorders of sex development and found that whole-exome sequencing is more effective than panel sequencing for molecular diagnosis. It identified regional genetic variation and emphasized next-generation sequencing's role in detecting variants related to gonadal and androgen-related genes.

This study found no evidence that androgen receptor copy number variation is associated with androgenetic alopecia, suggesting it is unlikely to be a contributing factor.

In this study, researchers found that massively parallel sequencing of mitochondrial DNA (mtDNA) can improve information recovery from forensic samples, with successful full region amplification possible from as few as 2,000 mtDNA copies, albeit with variability in heteroplasmy among hair samples from the same donor.

This study identified 374 eQTLs in scalp hair follicles associated with genes involved in metabolic, mitotic, immune processes, and responses to steroid hormones, contributing insights into genetic variation and hair traits.

This study found that the mammalian hairless gene encodes a corepressor protein that interacts with thyroid hormone receptors, providing insights into hair loss syndromes in humans and mice.

This study found that LGR5 is uniquely expressed in human corneal endothelial cells and maintains endothelial cell phenotypes while inhibiting mesenchymal transformation through the Wnt pathway.

This study found that keratin 6hf, a type II keratin, is expressed in specific regions of mouse and human hair and suggests potential interactions with keratin 17, impacting hair development and associated disorders.

This article discusses various skin pattern formations, their molecular mechanisms, and highlights the need for further understanding to connect molecular biology with organism phenotypes, without providing new clinical findings.

This study found that platelet-rich plasma may influence the proliferation of human hair dermal papilla cells by affecting gene expression related to the cell cycle.

This study identified a genetic locus associated with coat type in domestic dogs, showing certain variants linked to single-coated breeds and suggesting potential regulatory roles.

This review presents the practice of using hair bioelement analysis to assess nutritional status or environmental exposure, proposing complex interactions and hypotheses regarding depression and autism but reports no new clinical results.

This study examined the genetic basis for the curly hair trait in Mangalitza pigs, finding two specific genetic variants that contribute to this distinctive phenotype through autosomal dominant inheritance.

The document concludes that hair biology is complex and there are still unanswered questions about hair loss and follicle changes.

This study suggests that adult hair follicle stem cells can survive and potentially differentiate into neuronal cells after being transplanted in a mouse model of traumatic brain injury, indicating promise for TBI therapy.

This study concluded that the GIANT brain atlas, which integrates genetic and neuroanatomical variations, provides a more accurate representation of brain structure than traditional neuroanatomical atlases, allowing for better exploration of genetic influences on the brain.

In this study, the authors identified the DHRS9 SNP rs72623193 as most significantly associated with response to dutasteride in treating male pattern hair loss, with additional variants potentially contributing.

This study explored the molecular mechanisms determining the identity of keratinocytes and corneal epithelial cells, finding that miRNAs from the Gtl2-Dio3 region, which regulate key signaling pathways, play a significant role in cell identity through the Hox/Gtl2-Dio3 miRNA axis.

This study observed that EZH2 expression scores in the epidermis, dermis, and hair follicles decrease with gestational age in human fetuses, and these scores were significantly higher in adults, indicating that lower EZH2 levels may be required for full skin differentiation and maturation before birth.

Alopecia areata is linked to immune system differences, with specific biomarkers like CXCL9 and CXCL10 being key for diagnosis and potential treatment targets.