October 2025 in “Journal of Veterinary Clinics” In this case study, a Pomeranian was diagnosed with vaccine-induced ischemic dermatopathy, where different medication regimens gradually improved hair regrowth, though some lesions persisted after tapering treatment.
June 1996 in “Journal of Dermatological Science” Vitamin D3 applied to mouse skin caused more wrinkles and sagging due to changes in the skin's outer layer.
This study found that Meshushit, a new herbal ointment, enhanced granulation tissue formation and hair follicle preservation in treated burns compared to a control in an animal model.
270 citations
,
March 2012 in “Dermatologic Surgery” This study found that autologous platelet-rich plasma increased hair growth potential by enhancing dermal papilla cell proliferation and stimulating key signaling pathways in both cell cultures and mice models.
234 citations
,
February 2001 in “British Journal of Dermatology” FPHL affects hair density and diameter, causing visible hair loss in older women.
168 citations
,
August 2000 in “American Journal of Pathology” This study suggests that fibromodulin may regulate transforming growth factor-β activity during scar formation, influencing the transition from fetal scarless repair to adult scar-forming repair in rats.
153 citations
,
August 2002 in “Dermatologic Surgery” This paper introduces the Follicular Unit Extraction procedure and its accompanying FOX Test, finding that 60% of tested patients were suitable candidates for this minimally invasive hair transplantation method.
150 citations
,
June 2014 in “Biomaterials” This study found that 'smart' peptide hydrogels improved wound healing in a rat model of partial thickness burns, achieving greater wound closure and faster debridement compared to a standard treatment.
140 citations
,
December 2017 in “Journal of Controlled Release” This study reviews the evolution and modifications of microneedle drug delivery systems, initially designed for percutaneous use, now expanded for targeting a variety of tissues and organs such as ocular, oral mucosal, and gastrointestinal, suggesting widespread future applicability.
134 citations
,
January 2010 in “Biomedical research” This study found that subcutaneous administration of conditioned medium from adipose-derived stem cells promoted hair growth in mice, and hypoxia enhanced this effect by altering growth factor secretion.
127 citations
,
June 2006 in “International Journal of Pharmaceutics” This research found that liquid-state liposomes and niosomes may enhance finasteride delivery to pilosebaceous units in hamsters more effectively than gel-state vesicles or hydroalcoholic solution.
102 citations
,
July 2007 in “Genes & Development” This study found that maternal PPARγ is essential for preventing the production of inflammatory lipids in mouse milk, which can otherwise cause inflammation, alopecia, and growth retardation in nursing pups.
92 citations
,
September 2019 in “ACS nano” This study observed that a wearable electric stimulation device significantly promoted hair regeneration in rats and mice, outperforming conventional pharmacological treatments and enhancing growth factor secretion.
91 citations
,
April 2011 in “Journal of Ethnopharmacology” This study found that Polygonum multiflorum extract may promote hair growth by inducing the anagen phase in the resting hair follicles of mice.
91 citations
,
January 2009 in “International Journal of Trichology” This review discusses the advantages and limitations of various hair loss evaluation methods but reports no new results; it emphasizes the importance of cautious interpretation for these diagnostic tools.
87 citations
,
March 2005 in “Journal of Dermatological Science” This study found that the extract of Asiasari radix may promote hair growth in mice by enhancing protein synthesis, cell proliferation, and growth factor expression.
87 citations
,
September 2019 in “Nature Communications” In this study, researchers identified that upon tissue injury in a mouse model, epidermal cells at the wound edge convert to an embryonic-like state with SOX11 and SOX4 playing a central role in modulating epidermal development and cell migration genes.
86 citations
,
February 2003 in “Journal of The American Academy of Dermatology” This article discusses various mechanisms for promoting hair growth in pattern hair loss and highlights the challenge of balancing short-term measurable results in trials with the need for long-term efficacy data.
82 citations
,
March 1994 in “Archives of Dermatology” This study found that a 2% topical minoxidil solution significantly increased hair regrowth compared to placebo in women with androgenetic alopecia over 32 weeks.
77 citations
,
March 2021 in “Nature” In this study, increased corticosterone from chronic stress prolonged hair follicle stem cell quiescence in mice, inhibiting regeneration, but restoring Gas6 expression overcame this inhibition.
77 citations
,
January 1980 in “Carcinogenesis” This study found that TPA was significantly more effective than mezerein in inducing dark basal keratinocytes in mouse skin, which may be important in early tumor promotion stages.
76 citations
,
April 2013 in “PLoS ONE” The researchers reported that reactive oxygen species regulate the stress-induced SP-Mast cell pathway, which might support using antioxidants to treat stress-related hair loss.
75 citations
,
October 2002 in “Journal of Dermatological Science” This study found that Sophora flavescens extract may promote hair growth in mice by inducing earlier hair cycle changes and regulating growth factors in dermal papilla cells.
75 citations
,
January 1997 in “Journal of ethnopharmacology” This study found that Santolina oil was effective in controlling experimental candidiasis in both in vitro and in vivo settings and enhanced the effectiveness of clotrimazole against Candida albicans in vitro.
73 citations
,
March 2009 in “Seminars in Cutaneous Medicine and Surgery” This article reviews various diagnostic tools for hair disorders, describing methods ranging from invasive to noninvasive, but reports no new research findings or clinical results.
73 citations
,
March 2010 in “Food and Chemical Toxicology” This study found that Zizyphus jujuba essential oil enhanced hair growth in mice, with the 1% and 10% concentrations showing increased hair length compared to control.
68 citations
,
March 2018 in “Biomaterials” This study found that in vivo, a novel microneedle system for valproic acid delivery may improve hair regrowth efficacy by upregulating hair follicle development pathways more effectively than topical application.
67 citations
,
May 2007 in “Journal of Cosmetic Dermatology” This study found that topical formulations including extracts from Cuscuta reflexa, Citrullus colocynthis, and Eclipta alba significantly accelerated hair growth initiation and completion in rats, indicating potential benefits for treating alopecia.
65 citations
,
November 2016 in “Journal of The American Academy of Dermatology” This article reviews various types of primary cicatricial alopecias and emphasizes the importance of accurate diagnosis to improve management strategies, particularly detailing remaining lymphocytic forms and expanding on neutrophilic and mixed types.
63 citations
,
November 2009 in “British journal of dermatology/British journal of dermatology, Supplement” This study found that the subtilisin protease Sub3 from Microsporum canis is essential for adherence to the feline epidermis but is not necessary for invading epidermal structures.