Secreted Subtilisin Sub3 from Microsporum Canis Is Required for Adherence to but Not for Invasion of the Epidermis
November 2009
in “
British journal of dermatology/British journal of dermatology, Supplement
”
Studysummary This study found that the subtilisin protease Sub3 from Microsporum canis is essential for adherence to the feline epidermis but is not necessary for invading epidermal structures.
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The study concluded that the protease Sub3 from *Microsporum canis* was crucial for the fungus's adherence to feline epidermis but not for its invasion. Researchers used an RNA-silenced strain of *M. canis* and found a significant reduction in adherence to feline corneocytes, while invasion capabilities remained unaffected. This indicated that Sub3 was essential for the initial attachment phase of infection. The study utilized both ex vivo adherence models and in vivo guinea pig models, confirming the stability of the RNA-silenced strain and the specific role of Sub3 in pathogenicity.
