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Testosterone replacement therapy can prevent men from fathering children and should not be used by those wanting to stay fertile.

This review addresses the effects of testosterone on brain development and examines both the established sex differences in brain functions and the debate surrounding structural dimorphism in neuropsychiatric conditions.

This study found that long-term finasteride therapy in men with BPH worsened erectile dysfunction and reduced testosterone levels, while these effects were not observed with tamsulosin.

This review discusses the impact of testosterone therapy on postmenopausal women's sexual function and well-being but notes a lack of long-term safety studies and debates on defining androgen insufficiency.

This study found that Caesalpinia bonduc seed extracts significantly reduced prostate weight and improved prostate tissue morphology in Wistar rats with testosterone-induced benign prostatic hyperplasia.

This study found that while testosterone administration reduced myocardial damage in gonadectomized rats after ischemia/reperfusion injury, Finasteride led to greater improvements, whereas 4-hydroxyandrostenedione worsened outcomes.

In this animal study, finasteride was found to significantly lower cortisol and increase testosterone levels in female rats, indicating its broader impact on endocrine regulation by altering adrenal and gonadal hormones.

In this case study, a woman with congenital adrenal hyperplasia experienced substantial improvement in musculoskeletal and neurobehavioral symptoms after low-dose testosterone therapy, highlighting its potential role in managing chronic glucocorticoid overtreatment effects.

This study found that steroid hormones influence the quality indicators of fresh and cryopreserved stallion sperm, with testosterone negatively correlated with motility and estradiol positively correlated with survival rate.

This study found that variations in sleep patterns, free testosterone, and 5-alpha-reductase type 1 activity are associated with changes in sebum excretion in women, which may contribute to variability in acne studies.

This study found that the GGC repeat length significantly influenced testosterone levels in oral contraceptive users from high-risk breast cancer families, and homozygosity for short alleles may be linked to increased breast cancer risk.

In this systematic review, researchers observed that Toxoplasma gondii infection is associated with alterations in testosterone levels, generally increasing in humans but showing mixed effects in animals, highlighting a complex relationship that warrants further investigation.

This study found that methanolic extract of Cordia plathytyrsa increased testosterone levels in male rats but did not affect other evaluated metabolic parameters.

This study found that 4 weeks of finasteride treatment significantly decreased DHT levels in bald scalp to levels similar to hair-containing scalp in men with male pattern baldness.

This study found that overexpression of AKR1C3 in prostate cancer cells redirected androgen metabolism towards testosterone production, which facilitated cell proliferation, potentially reducing the effectiveness of finasteride treatment.

This review refutes several myths about testosterone therapy in women and suggests that testosterone is beneficial for both physical and mental health, though its safety in women continues to be researched.

The researchers suggest that testosterone levels might influence COVID-19 susceptibility and severity, with low levels potentially protecting against infection but possibly worsening severe disease due to cytokine storm activation.

In this review, the role of DHT in male-type obesity and metabolic diseases is discussed, with increased levels potentially exacerbating cardiovascular disease risk; the paper reports no new results.

This study found that young women with female-pattern hair loss exhibit increased testosterone production rates while dihydrotestosterone production rates remain within or below the normal range.

This study examines the interaction between androgen receptor signaling and the β-catenin/Wnt signaling pathway in mouse hair follicles, but reports no clinical results.

In this study, researchers found no significant differences in serum levels of DHEAs, DHT, and testosterone between female patients with oral lichen planus and healthy controls, suggesting no neuroendocrine etiology linked to the condition.

This review concluded that for women, the benefits of testosterone implants are outweighed by risks, with possible higher rates of irreversible adverse effects than previously reported.

This study found that ethanol extract of Syzygium aromaticum (clove) leaves significantly improved lipid profiles and increased body weight in testosterone-induced benign prostatic hyperplasia rats, suggesting potential anti-hyperlipidemic effects and modulation of body weight through metabolic activity.

This narrative review concludes that long-term randomized controlled trials are needed to establish clear guidelines for testosterone therapy in women, given the lack of FDA-approved formulations and the variable quality of current treatments.

In this study, researchers found no significant differences in the serum levels of DHEAs, DHT, and testosterone between female patients with oral lichen planus and healthy controls, suggesting no neuroendocrine etiology is associated with this condition.

This study suggests that the testosterone analogs 7α-Methyltestosterone and 7α-Ethyltestosterone may offer promising androgenic, progestogenic, and anabolic properties for development as male contraceptives.

This review examines the development of cardiovascular risk factors related to testosterone levels in PCOS women and reports no new clinical results.

This study demonstrated that cortisol, estradiol, and testosterone are preserved in archaeological human hair, allowing for the analysis of ancient stress and reproductive hormone patterns.

This study suggests that synthetic steroid analogues or 5α-reductase modulation could be potential therapeutic strategies for nervous system disorders, but further research on their effects is necessary.

In this study of male patients with 46,XY 5α-reductase type 2 deficiency, DHT therapy was effective in achieving penile enlargement during infancy, while testosterone replacement therapy proved more beneficial during puberty, possibly due to increased conversion to DHT.