Modification of Testosterone Levels With Piptadeniastrum Africanum and Cordia Plathytyrsa May Influence Metabolic Parameters in Wistar Rats

    July 2022 in “ World Journal of Advanced Research and Reviews ”
    Mary-Ann Angie Mbong, Françoise Raïssa Ntentié, Boris Gabin Kingue Azansta, Gislain Paka Djiokeng, Henriette Thérèse Dimodi, Janvier Aimé Fotso Youovop, Inelle Makamwé, Huiny Miriane Fotso Tiénou, Enyong Julius Oben
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    TLDR Piptadeniastrum africanum and Cordia plathytyrsa can increase testosterone without major metabolic changes, but may affect triglycerides and creatinine.
    The study investigated the effects of methanolic extracts from Piptadeniastrum africanum and Cordia plathytyrsa on testosterone levels and metabolic parameters in male Wistar rats. The extracts were administered orally for 15 days, and results showed a significant increase in testosterone levels by up to 93% compared to controls. However, the extracts did not induce oxidative stress or alter total cholesterol, glycemia, serum protein levels, or markers of hepatic toxicity. Notably, P. africanum increased triglyceride levels, and a higher dose of C. plathytyrsa raised creatinine levels. The study concluded that while C. plathytyrsa enhanced testosterone synthesis, it did not affect all evaluated metabolic parameters.
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