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Certain defective glucocorticoid receptor mutants move faster inside cell nuclei and work less effectively.

Mutations in the glucocorticoid receptor gene cause reduced sensitivity to glucocorticoids and may lead to poor response to treatment.

Certain proteins, Lgr5 and Lgr6, are important markers of adult stem cells and are involved in tissue repair and cancer development.

Brg1 is crucial for keeping hair follicle stem cells and repairing skin, working with the Sonic Hedgehog pathway to promote hair growth.

Most hair follicle stem cells do not protect their DNA by dividing it unevenly.

Certain transcription factors are key in controlling skin stem cell behavior and could impact future treatments for skin repair and hair loss.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

The article concludes that while we understand a lot about how melanocytes age and how this can prevent cancer, there are still unanswered questions about certain pathways and genes involved.

The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.

The conclusion is that the nuclear lamina and LINC complex in skin cells respond to mechanical signals, affecting gene expression and cell differentiation, which is important for skin health and can impact skin diseases.

The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.

Cellular senescence has both cancer-blocking and cancer-promoting effects, and targeting senescent cells may improve health and lifespan.

The document suggests that targeting the hormone DHT could be a more effective treatment for prostate cancer than targeting testosterone.

A new mutation in the hairless gene causes hair loss and skin wrinkling in mice.

Male pattern baldness involves hormones and cell signals affecting hair growth.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

Some stem cells in the body rarely divide, which could help create better treatments for diseases and aging.

Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.

A circular RNA helps cashmere goat hair cells become hair follicles by blocking a molecule to boost a gene important for hair growth.

Skin stem cells remember past inflammation, helping them respond better to future injuries and possibly aiding in treating skin issues.

Sebaceous glands can heal and regenerate after injury using their own stem cells and help from hair follicle cells.

Hairless mammals have genetic changes in both their protein-coding and regulatory sequences related to hair.

DNA methylation is essential for skin and hair follicle development, and could be a target for treating skin diseases.

SOX2 is crucial for skin cell function and hair growth, and it plays a role in skin cancer and wound healing.

Astrotactin2 affects hair follicle orientation and skin cell polarity.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

MicroRNAs are crucial in controlling cell signaling, affecting cancer and tissue regeneration.

β-catenin is essential for stem cell activation and proliferation in hair follicles.