research Hair removal and bioavailability of chemicals: Effect of physicochemical properties of drugs and surfactants on skin permeation ex vivo
Hair removal methods damage the skin barrier and affect substance penetration.
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research Using proteomics to compare the molecular structures of sulfide and permeate-depilated sheepskins
This study observed that using an environmentally friendly bovine milk permeate effectively and cleanly removes wool from sheepskins without harming the skin, and results in smoother leather compared to traditional chemical methods.
research Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis
This study found that hair shaft miniaturization in aging and genetic hypotrichosis leads to hair follicle stem cell loss through mechanical compression and apoptosis mediated by the Piezo1 channel.
research Faculty Opinions recommendation of Mechanical stretch induces hair regeneration through the alternative activation of macrophages.
This study found that applying the right mechanical stretch to skin can activate hair stem cells and promote hair regeneration through a pathway involving WNT, BMP-2, and M2 macrophages.
research Nestin as a marker of unipotent epithelial progenitor cell differentiation into outer root sheath keratinocytes in embryonic and adult hair follicles
This study found that nestin-expressing unipotent progenitor cells capable of differentiating into outer root sheath keratinocytes are present during hair follicle development and in adult hair follicles.
research Nestin as a marker of unipotent epithelial progenitor cells differentiate into outer root sheath keratinocytes in embryonic and adult hair follicles
This study revealed that nestin-expressing progenitor cells capable of becoming ORS keratinocytes are present during both hair follicle development and in adult hair follicles.
research The Effect of Different Preoperative Depilation Ways on the Healing of Wounded Skin in Mice
This study found that electric shaving was the most effective and safest method for preoperative hair removal in mice, compared to depilatory cream and sodium sulfide, which negatively affected wound healing.
research Role of Non Androgenic Factors in Hair loss and Hair Regrowth
This article discusses how nutritional and environmental factors, along with antioxidant supplementation, may improve hair growth by mitigating the effects of androgens and reports no new clinical results.
research Epoxy Fatty Acids and Inhibition of the Soluble Epoxide Hydrolase Selectively Modulate GABA Mediated Neurotransmission to Delay Onset of Seizures
The researchers found that inhibiting soluble epoxide hydrolase, either genetically or pharmacologically, delayed the onset of chemically induced seizures related to GABA antagonism in experimental models.
research Hair & Cutaneous Development
The document presented various studies on hair and cutaneous development, revealing insights into hair biology and potential therapeutic targets for hair-related conditions. Key findings included the role of stem cells and their niches in hair regeneration, the impact of TACE/ADAM17 depletion on alopecia, and the expression of somatostatin in hair follicles. Research on genetic factors, such as CYLD mutants and P-cadherin, highlighted their importance in hair growth and pigmentation. Studies on hair aging identified genes involved in hair loss in women over 40. Additionally, the potential of keratinocyte precursors from iPS cells for hair follicle regeneration and the effectiveness of a parathyroid hormone analog in reversing chemotherapy-induced alopecia were explored. The document also discussed the role of cholesterol biosynthesis in cicatricial alopecia, the necessity of Wnt signaling for hair follicle initiation, and the effects of ATP-sensitive potassium channel blockers on hair growth. These findings collectively advanced the understanding of hair growth, alopecia treatment, and skin regeneration.
research Photodegradation of human hair: a microscopy study
This study found that UV stabilizers must diffuse uniformly and in high uptake levels throughout hair fibers during humidification cycles to effectively prevent photo-oxidative degradation.
research Hair Lipid Structure: Effect of Surfactants
In this study, researchers highlighted that while hair lipids are crucial for hair health and protection, surfactants in shampoos and conditioners can partially remove these lipids, potentially affecting hair structure, though the exact mechanisms remain poorly understood and require further investigation.
research MCPIP1 controls effects of myeloid cells on skin carcinogenesis and hair growth
In a mouse model study, researchers observed that the absence of MCPIP1 in myeloid cells decreased susceptibility to chemically induced skin papillomas but caused significant hair loss and skin pigmentation changes, suggesting a role for MCPIP1 in skin carcinogenesis and follicle integrity.
research Prevention of lipid loss from hair by surface and internal modification
This study investigated lipid loss in hair caused by surfactants and found that surface and internal modifications can significantly protect different lipids from depletion, with internal modification preventing 52.0 to 81.3% of lipids in certain groups.
research Loss of Dicer in Newborn Melanocytes Leads to Premature Hair Graying and Changes in Integrin Expression
This study found that stress-induced inactivation of the enzyme Dicer in melanocytes can cause premature hair greying by preventing proper melanocyte placement and melanin transfer in mice, suggesting the Dicer-miR92b-ItgaV pathway as an important link between stress and grey hair.
research Tetrathiomolybdate Decreases the Expression of Alkaline Phosphatase in Dermal Papilla Cells by Increasing Mitochondrial ROS Production
This study identified that copper depletion in dermal papilla cells reduced hair growth by boosting ROS levels, but ROS scavengers like NAC and ascorbic acid partially alleviated this effect.
research Comparative Study of the Effect of UV- VS. Gamma Radiation on Human Hair
This study found that human hair shows progressive damage from UV and gamma radiation exposure, with fluorescence intensity serving as a sensitive measure of radiation-induced changes.
research Metformin and Amoxicillin/Clavulanate as Co-Administration for the Treatment of Hyperglycemia in Female Rats Caused by Alloxan.
In this study with diabetic rats, the researchers found that combining Amoxicillin/Clavulanate with metformin may enhance the glucose-lowering effects of metformin, without affecting cholesterol, triglycerides, or certain electrolytes.
research Do Hair Bulb Melanocytes Undergo Apotosis During Hair Follicle Regression (Catagen)?
In this study, different types of catagen in the C57BL/6 mouse model exhibited varying effects on hair follicle melanocytes and melanin distribution, with spontaneous and dexamethasone-induced catagen showing pigment incontinence, while cyclophosphamide-induced catagen retained dendritic melanocytes but increased ectopic melanin.
research The eosinophilia-myalgia syndrome
This review discusses the emergence and impact of eosinophilia-myalgia syndrome related to L-tryptophan and offers insights into environmental factors affecting sclerodermatous conditions, with no new research findings presented.
research Quoi de neuf en recherche dermatologique ?
2011 dermatological research found new skin aging markers, hair loss causes, skin defense mechanisms, and potential for new treatments.
research The TFIID subunit TAF4 regulates keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity in mouse epidermis
In this study, inactivating the TAF4 subunit of transcription factor TFIID in mouse epidermis disrupted gene expression linked to skin and hair function, and increased tumor risk.
research Immunological challenges associated with artificial skin grafts: available solutions and stem cells in future design of synthetic skin
This review discusses the challenges of skin graft acceptance and examines current strategies and alternatives for full-thickness skin replacement and repair, noting that immunological rejection remains a significant hurdle.
research Allergens of permanent hair dyes induces epidermal damage, skin barrier loss and IL-1 α increase in epidermal in vitro model
This study found that mixtures used in permanent hair dyes had irritant effects on reconstructed human epidermis, while individual ingredients alone did not.
research Headgear-induced temporary pressure alopecia
In this study, a 13-year-old boy developed temporary pressure alopecia from wearing orthodontic headgear, which resolved after discontinuation, highlighting a rare side effect that can affect psychosocial wellbeing.
research Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF
This study shows that macrophage-induced TNF signaling can activate hair follicle stem cells and promote new hair follicle formation after wounding by regulating AKT/β-catenin pathways.
research Epithelial Cells in the Hair Follicle Bulge do not Contribute to Epidermal Regeneration after Glucocorticoid-Induced Cutaneous Atrophy
This study found that follicular stem cells in hair follicles are more sensitive to the antiproliferative effects of glucocorticoids compared to basal keratinocytes due to incomplete desensitization.
research Ascorbigen Induces Dermal Papilla Cell Proliferation in Vitro , but Fails to Modulate Chemotherapy-Induced Alopecia in Vivo
This study found that ascorbigen increased growth of dermal papilla cells but did not significantly protect against chemotherapy-induced alopecia in a mouse model, suggesting limited effectiveness for hair regrowth in this context.
research Stingless bee propolis promotes hair follicle regeneration and melanocyte function in chemotherapy-induced alopecia mouse model
In this murine study, researchers found that topical treatment with Philippine stingless bee propolis increased folliculogenesis, epidermal thickness, and melanogenesis, but not hair length, potentially supporting hair follicle regeneration and melanocyte function in chemotherapy-induced alopecia models.
research Protective role of Nigella sativa in chemotherapy-induced alopecia
In this study, N. sativa oil and decoction significantly protected against chemotherapy-induced alopecia in albino rats.